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Discovery, purification and characterization of antifungal proteins and other defense-related compounds from tropical plants.
(1999)
To date, we have screened 164 extracts from over 100 different plant species for antifungal activity against Fusarium chlamydosporum, a saprophytic/pathogenic fungus. Out of these 164 crude extracts, 111 had antifungal ...
Low-molecular-weight branched polyethylenimines: Multifunctional beta-lactam potentiators against resistant Gram-negative pathogens
(2022-05-13)
Antibiotic resistance is a simmering threat to the global public health system. Currently, it is estimated by the Centers for Disease Control and Prevention that at least 2.8 million people in the US get infected with ...
Conformational dynamics and structure of FepA, a ligand-gated channel in the bacterial outer membrane.
(1998)
Since Waring & Werkman documented a microbial requirement for iron in 1944, much progress has been made in understanding how microbes assimilate this mundane but biological precious metal. The proteins involved in iron ...
Purification, Mechanism, and Biochemical Interactions of the Essential Mycolic Acid Transporters MmpL3 from Mycobacterium tuberculosis, and CmpL1 from Corynebacterium glutamicum.
(2020-06)
The Corynebacterium – Mycobacterium – Nocardia family (CMN family) are a subset group of actinomycetes which are characterized as acid-fast, Gram-positive species. Many members of the CMN family are causative agents of ...
Purification, characterization and cDNA cloning of a trypsin inhibitor from Pentaclethra macroloba.
(1998)
The larval growth of the European corn borer, Ostrinia nubilalis , was reduced when grown on artificial diet containing either purified PmTI or PmSTI fusion protein expressed in E. coli. Likewise, high mortalities were ...
Characterization of a Sporulation Related Two-Component Signaling System in Clostridioides difficile
(2023-12-15)
Clostridioides difficile is a spore-forming anaerobic human pathogen, that is commonly associated with antibiotic therapy in adults. The disturbance of the gut microbiota, typically caused by antibiotics, allows for an ...
Physiology and biochemistry of purine salvage in an archaeobacterium, Methanobacterium thermoautotrophicum.
(1997)
Studies of the effect of temperature on stability of 100-fold purified HGPRTase from M. thermoautotrophicum suggested that this enzyme is the most thermostable of all known HGPRTases; upon incubation at 92$\sp\circ$C ...
Iron uptake in Gram-negative and Gram-positive bacteria.
(2006)
Bacteria, including both Gram-positive and Gram-negative bacteria, utilize iron sources from the environment. Iron uptake systems in Gram-negative bacteria are well studied. Escherichia coli FepA transports certain catecholate ...
Stressed Out: Resistance-nodulation-division (RND) and Major Facilitator Superfamily (MFS) Efflux Pump Mediated Survival Strategies of Acinetobacter baumannii
(2024-05-11)
Originally discovered in soil microbial communities, reports of genus Acinetobacter associated infections started to increase around 1977 and continued to climb to frightening heights for the next 20 years resulting in ...