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Advancement of Natural Products: Optimization of Instrumentation and Examples of their Application to the Isolation of New Compounds
(2019)
The world of natural products has a long rich history dating back thousands of years and was the origin of medicine as we know it. Advancements in the field of natural products can be seen not only in the isolation of new ...
SINGLE CELL METABOLOMICS USING MASS SPECTROMETRY: DEVICES, METHODS AND APPLICATIONS
(2019-05-10)
Cells are basic functional components of eukaryotic organisms containing rich biological and physiological information. To investigate the nature of cells, a variety of fundamental and mechanistic studies of the cell ...
Stereoselective Spirocyclizations Initiated by Metal Carbenes
(2019-05-10)
Within the field of drug design, there is a great interest in the development of synthetic libraries that mimic the structural complexity of natural product scaffolds. Recent cheminformatic analyses have revealed that 83% ...
THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS
(2019-05)
The overall goal of my work was to probe the structural biology of drug metabolite protein interactions and to correlate this with the negative side effects associated with many prescription drugs. More specifically, the ...
DEVELOPMENTS AND APPLICATIONS OF HIGH-THROUGHPUT TOP-DOWN PROTEOMICS
(2019)
Emerging technologies for liquid chromatography (LC) separations and mass spectrometry (MS) have dramatically improved the throughput of top-down proteomics, which has allowed the identification of thousands of intact ...
MOLYBDENUM(VI) BIS(AMIDATE) COMPLEXES FOR GROUP TRANSFER REACTIONS AND CATALYSIS
(2019-05-10)
Molybdenum complexes bearing bidentate amidate ligands have been synthesized and characterized using nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (FTIR), and in most cases, single crystal X-ray ...
UNDERSTANDING THE ALKYL DONOR SPECIFICITY OF AROMATIC PRENYLTRANSFERASES
(2019-06-21)
Chemoenzymatic synthesis is a leading technique in the diversification and late stage modification of complex molecules, due to the high regio and stereo specificities of the enzymes. Over the last decade, the broad aromatic ...
The Caseinolytic Protease P System in Clostridium difficile
(2019-05-10)
Clostridium difficile is a Gram-positive, spore-forming, toxin producing pathogen that has rapidly gained resistance to several broad-spectrum antibiotics. C. difficile infection (CDI) is a leading cause of hospital-acquired ...
DNA Barcoding Identification and Chemical Investigation of Fungi
(2019-05-10)
Fungi represent a diverse resource in the discovery of new secondary metabolites which have been successfully developed as drugs such as antibiotics, immunosuppressant and stains. However, there are still problems which ...
Characterization and bioinformatic analysis of Pseudomonas aeruginosa condensins
(2019-12)
DNA is organized within chromosomes not only to permit a large amount of DNA to occupy a very small space, but also to serve essential functional roles. Varied levels of organization enable proper DNA replication, repair, ...