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THE DEVELOPMENT OF FERROCENE-MODIFIED LINEAR POLY(ETHYLENIMINE) REDOX POLYMERS AND THEIR APPLICATION IN AMPEROMETRIC GLUCOSE BIOSENSORS AND COMPARTMENT-LESS BIOFUEL CELLS
(2010)
A series of redox polymers was synthesized by attaching various ferrocene derivatives to linear poly(ethylenimine) (LPEI). These polymers displayed a remarkable ability to shuttle electrons from the active site of the ...
Filamentous Biological Macromolecules Based Nanostructures and Their Applications
(2010)
In nanoscience, one promising strategy for achieving precise placements of nanomaterials and specific recognitions between individual build blocks is to use self-ordered templates to arrange them into designed pattern. ...
NATURAL PRODUCTS AS A SOURCE OF NEW THERAPIES FOR NEURODEGENERATIVE DISEASE AND EFFORTS TOWARD THE DEVELOPMENT OF A METABOLOMICS-BASED DRUG DISCOVERY PLATFORM
(2010)
Natural products have traditionally played an important role in drug discovery research. They have been particularly important in the search for therapies for neurodegenerative diseases. Although there are numerous forms ...
PROBING THE MECHANISM OF SACCHAROPINE DEHYDROGENASE FROM Saccharomyces cerevisiae USING SITE-DIRECTED MUTAGENESIS
(2010)
Saccharopine dehydrogenase (SDH) catalyses the NAD-dependent oxidative deamination of saccharopine to give L-lysine and alpha-ketoglutarate. There are a number of conserved hydrophilic, ionizable residues in the active ...
MOBILITY STUDY OF PROTEIN AND DYE MOLECULES WITHIN SILICA HYDROGEL, LIPOSOMES, AND BACTERIA CELLS BY FLUORESCENCE MICROSCOPY
(2010)
Fluorescence techniques are very useful for understanding the various processes in biological science. This thesis presents the applications of several fluorescence techniques for studying the mobility of proteins and ...
Ligand Assisted Copper Catalyzed C-H Amination
(2010)
The presence of nitrogen in amino functional groups found in many useful natural and synthetic products makes their preparation valuable to chemicals and materials production, biology and medicinal chemistry. Their importance ...
Heme and Hemoglobin Transport Systems of Listeria monocytogenes
(2010)
Heme (Hn) is an important iron source for Listeria monocytogenes, an intracellular pathogen that causes listeriosis. I characterized listerial Hn acquisition by two Fur-regulated genetic systems: the hup region that produces ...
MECHANISTIC AND STRUCTURAL STUDIES OF SACCHAROPINE DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE
(2010)
Lysine is an essential amino acid in mammals including humans. The α-aminoadipate (AAA) pathway for lysine biosynthesis is unique to fungal organisms and enzymes of this pathway are of interest as potential targets ...
Nitrogenation of Hydrocarbons via Transition-Metal and Non-Metal Catalysis
(2010)
The overall objective in the Nicholas Group's Amination Project is to develop
CATALYST EVOLUTION VIA DYNAMIC COMBINATORIAL CHEMISTRY
(2010)
Dynamic combinatorial chemistry (DCC) is a combinatorial method of synthesis utilizing complex mixtures under thermodynamic control, called dynamic combinatorial libraries (DCL). The addition of a template molecule which ...