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Diffuse Optical Tomography of Spontaneous Brain Fluctuations in Humans
(2022-05-13)
In the absence of tasks or external stimuli, the human brain produces recordable spontaneous low-frequency fluctuating hemodynamic signals, which show temporally-correlated activity among brain regions forming a so-called ...
MODELLING AND VERIFICATION OF THERMOACOUSTIC MEDICAL IMAGING FROM NANOSCOPIC TO MACROSCOPIC RESOLUTIONS
(2019-12-13)
In this thesis, three main questions regarding the potential of thermoacoustic imaging are answered: 1) what are the conventional resolution limitations of photoacoustic imaging and how can they be extended to enable ...
Electromyographic Measurement of the Chinchilla Middle Ear Muscle Reflex Elicited by Acoustic or Blast Stimuli
(2019-05-10)
Hearing damage is a widespread problem that can cause social isolation and reductions in quality of life. A wide range of conditions including extended exposure to noise or near-instantaneous exposure to blast overpressure ...
Blast wave transmission through the ear with computational and 3D printed models and assessment of cochlea damage with SEM imaging
(2021-05-14)
Blast-induced injuries affect the health of service members, veterans, and other victims, in which the auditory system is often damaged rupturing the tympanic membrane (TM) and reducing the number of viable cochlear hair ...
Establishing elemental analysis to quantify nanoscale interactions at single nanoparticle and single cell levels
(2021-12-17)
For over two decades, nanoscale materials have been utilized as diagnostics and therapeutics. The successful clinical implementation of these platforms depends on well-defined physicochemical properties. However, such ...
A novel polysaccharide-based surface engineering strategy for nanomedicines
(2022-08-04)
This dissertation presents the development and evaluation of a novel polysaccharide-based surface engineering strategy for nanomedicines.
Chapter one summaries the current status of nanoparticle toxicology. Nanoparticles ...
Improving Quantification of Nanoscale Interactions by Engineering Monodisperse Gold Nanoparticles
(2023-08-04)
Mechanisms of nanoparticle-cell interactions are dependent upon the size of the administered nanoparticles. At pre-clinical and clinical levels, precise control over the size and monodispersity of nanoparticles is required ...
DEVELOPMENT OF BIOMATERIALS FOR CALVARIAL BONE REGENERATION AND APPLICATION TO TRAUMATIC BRAIN INJURY
(2017)
In the treatment of severe traumatic brain injury (TBI), a two-stage surgical intervention is routinely performed. In the first surgery, decompressive craniectomy (DC) is performed to remove a large portion of calvarial ...
Engineering a peptide-based tool for biomedical applications
(2022-12-16)
Numerous technological and scientific advancements have been developed by the structural organization and functional capabilities of natural materials. A field known as "biomaterials" focuses on adapting engineering concepts ...
Development of Patient-Specific Shape Memory Polymer Foams for the Treatment of Intracranial Aneurysms
(2023-05-12)
The objectives of this research include: (1) designing an electrically conductive shape memory polymer (SMP) material, (2) developing a method for the systematic fabrication of SMPs with complex three-dimensional geometries ...