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TonB dependent transport processes through Escherichia coli FepA.
(2007)
One of the previously proposed mechanisms of TonB is called the "shuttle hypothesis" which states that TonB shuttles from the inner membrane to the outer membrane. The data presented here demonstrates that TonB does not ...
The role of membrane fusion proteins in transport of diverse substrates in bacteria.
(2007)
Multidrug resistance (MDR) efflux pumps are increasingly recognized as major contributors to resistance in clinically resistant isolates. MDR is associated with increased morbidity and mortality in hospitals and is a serious ...
Synthesis of symmetrical and optically active alpha-amino acids via homologation of nickel(II) complexed glycine Schiff bases.
(2007)
In order to overcome some of the limitations associated with the previously described Ni(II) complexed NGE a new generation of modular Ni(II) complexed NGE were introduced. The flexibility of this modular design has allowed ...
Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe.
(2007)
The yeast two-hybrid assay indicates that MPR1 interacts with the response regulator domains of MAK3 (one of the three histidine kinases) and MCS4, but not with MAK1, MAK2 and PRR1. PRR1-RR weakly interacts with MAK1-HK, ...
Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae.
(2007)
A proton shuttle chemical mechanism is proposed on the basis of the pH dependence of kinetic parameters, dissociation constants for competitive inhibitors, and isotope effects. In the direction of lysine formation, once ...
Testing recently-developed molecular dynamics protocols for structure prediction of polypeptides and prion proteins.
(2007)
Two MD protocols were recently developed that allow a polypeptide to search the PE surface in search of the global PE minimum, which should correspond to the experimental structure. alpha-helical secondary structures have ...
Sequencing and comparative genomics of Leptospira interrogans serovar pomona and Leptospira kirschneri serovar grippotyphosa.
(2007)
Virulence genes that include methyl-accepting chemotaxis protein, flagellar basal body-associated protein, flagellar motor switch protein, Lig A protein, thermolysin, multiple antibiotic resistance protein, acriflavine ...
Investigation of matrix interferences in quantitative liquid chromatography-electrospray ionization mass spectrometry analysis of biological samples.
(2007)
The mechanisms by which endogenous GPCho lipids interfere with analyte electrospray ionization were investigated with the aid of a partition equilibrium mathematical model. A linear equation, which was derived by modifying ...
Interactions of nitric oxide and nitrosamines with group 8 metalloporphyrins.
(2007)
Chapter 1 of this dissertation introduces the importance of nitric oxide in biological systems.