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X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS
(2016-05)
This thesis describes research into the roles that metalloproteins and non-metalloproteins play in the biological inorganic/organic chemistry of common nitrogen oxides. There are three main chapters on this work: the first ...
A COMPUTATIONAL APPROACH FOR ACCESSING PHOSPHORYLATED RESPONSE REGULATOR CONFORMATIONS AND SIGNALING COMPLEXES INVOLVING THE FUNGAL PHOSPHORELAY PROTEIN YPD1
(2016-08)
Two-component signaling is the primary means by which bacteria, archaea and certain
eukaryotes sense and respond to their environments. Signal transfer proceeds through
sequential His-to-Asp phosphorylation of upstream ...
Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps
(2016-08)
Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of ...
Oxo-Rhenium Catalyzed Transformation of Alcohols: Deoxydehydration and Reductive Coupling
(2016-08)
One of the challenges for the future is to find alternative energy and chemical resources to petrol. Biomass-derived feedstocks offer a renewable source of highly oxygenated molecules. Recent chemical processes for the ...
THE BIOCHEMICAL CHARACTERIZATION OF TWO PHOSPHORELAY SIGNALING PROTEINS: YPD1 HOMOLOGS FROM SACCHAROMYCES CEREVISIAE AND CRYPTOCOCCUS NEOFORMANS
(2016-08)
Histidine-to-aspartate multi-step phosphorelay systems are used extensively by eukaryotes and bacteria to sense and respond to changes in their external environment and to control the regulation of crucial biological ...
TEMPERATURE-INDUCED SPECTRAL ARTIFACTS IN FOURIER TRANSFORM INFRARED (FTIR) SPECTROSCOPY. OPTIMIZATION OF VARIABLE TEMPERATURE DIFFUSE REFLECTION FTIR SPECTROSCOPY INSTRUMENTATION
(2016-12-16)
High stability Fourier transform infrared (FT-IR) interferometers make it possible to conduct experiments designed to identify subtle sample structure changes resulting from external perturbations. In particular, variable ...
TARGETING PLASMODIUM INVASION PATHWAYS IN MOSQUITOES TO BLOCK MALARIA TRANSMISSION
(2016-12)
Malaria remains a devastating disease. Transmission-blocking vaccines (TBVs) are being considered as a promising approach to eliminate Plasmodium infection. However, the challenges in developing such a vaccine are paramount, ...
TARGETED GENE DELIVERY TO MESENCHYMAL STEM CELLS USING NANOPARTICLES
(2016-05-13)
Stem cells hold great potential for the regenerative medicine and tissue engineering. Controlling the fate of stem cell in a reliable method still remains a problem. The strategies for directing the fate of stem cells ...