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A STUDY OF HYPOSELENOCYANITE AND THE KINETICS AND MECHANISM OF THE LACTOPEROXIDASE SYSTEM
(2018-12-14)
The lactoperoxidase system, defined as lactoperoxidase in the presence of hydrogen peroxide and thiocyanate, is a powerful method of host defense, particularly in mammalian secretory mucosae. The product of this system, ...
Enhanced Sampling Methods for Molecular Dynamics Simulations of Proteins
(2018-12)
Due to the many folds existing in nature, proteins are able to perform a multitude of functions within cells. This relationship between structure and function is one of great importance and has added to the understanding ...
THE LIGAND BINDING PROPERTIES OF THE OXYSTEROL-BINDING PROTEIN FAMILY SUBFAMILY-I
(2018-12-14)
The oxysterol-binding protein/OSBP-related proteins (OSBP/ORPs) are a family of proteins conserved in all eukaryotes that have complex biological activities connected to lipid transport and lipid regulation. OSBP is ...
DEVELOPMENT OF BENCHTOP CAPILLARY-BASED ANALYTICAL INSTRUMENTS FOR CHROMATOGRAPHIC SEPARATION AND DETECTION
(2018-05-01)
Point-of-Care (POC) analysis in recent years has driven the need for the miniaturization of chemistry instruments in the analytical field. One such instrument class involves chromatographic systems for the separation and ...
Design and Synthesis of OSW-1 Analogs and Other Bioactive Small Molecules for Potential Therapeutic Applications
(2018)
OSW-1 is a cholestane glycoside natural product with potent anti-proliferative activity, broad spectrum anti-viral activity, and a novel mechanism of action. The OSW-1’s cellular targets are oxysterol-binding protein (OSBP) ...
Determinants of gene targeting and regulation by response regulators in Clostridioides difficile
(2018-12-14)
Bacteria use two-component signal transduction systems to sense the conditions of the environment and adapt their behavior to ensure survival. The separate roles of signal perception and response output are carried out by ...
Development of phage display-derived targeted cancer therapy and net-work scaffold for 3D cancer cell culture
(2018-12-14)
Precision medicine emphasizes the patient-specific formulation for treating diseases, especially cancer. For targeted cancer treatment, however, since the expression level of tumor receptors on each patient varies even for ...
Exploring the cellular effects of small molecule inhibitors of Oxysterol-binding Protein
(2018-12-14)
Oxysterol-binding protein (OSBP) is the founding member of a conserved protein family found among eukaryotes that functions as a lipid transporter between the ER and Golgi. OSBP is ubiquitously expressed in all tissues and ...
Branched polyethylenimine re-sensitizes methicillin-resistant Staphylococcus aureus to beta-lactam antibioitics through a novel mechanism of action
(2018)
Methicillin-resistant Staphylococcus aureus (MRSA) is a growing concern in the medical industry due to high morbidity and difficulty of treatment in infected patients. Conventional β-lactam antibiotics kill Staphylococcus ...
Investigations of Secondary Metabolites from Fungi: Isolation, Structure Elucidation, and Computational Studies
(2018-12-14)
Natural products have served as therapeutic agents in the treatment of many human health ailments for thousands of years. In order to find new therapeutic agents for future human health problems, those in the field of ...