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Capillary-based analytical technique developments for analysis of bio-sample
(2017-05)
Analytical chemistry plays a significant role in bioscience research. Bio-samples, such as DNA and proteins, are often used for identification purpose or disease related research. Analyzing a biological sample typically ...
The Nature of Water in Bacterial Spores, Sporicidal Activity of Chlorine Dioxide, and Cryoprotectant Properties of Poly(adenylic) Acid
(2013)
Water is the fundamental chemical molecule of life, and the nature of how water interacts with living organisms and how living organisms can maintain liquid water for metabolic function below freezing (cryoprotection) is ...
Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter
(2013)
In Gram-negative bacteria, intrinsic antibiotic resistance is provided by three component efflux transporters. In Escherichia coli, MacAB-TolC is the first experimentally described ATP-driven tripartite efflux pump responsible ...
The Caseinolytic Protease P System in Clostridium difficile
(2019-05-10)
Clostridium difficile is a Gram-positive, spore-forming, toxin producing pathogen that has rapidly gained resistance to several broad-spectrum antibiotics. C. difficile infection (CDI) is a leading cause of hospital-acquired ...
DNA Barcoding Identification and Chemical Investigation of Fungi
(2019-05-10)
Fungi represent a diverse resource in the discovery of new secondary metabolites which have been successfully developed as drugs such as antibiotics, immunosuppressant and stains. However, there are still problems which ...
Ferrocene-Modified Linear Poly(ethylenimine) Bioelectrode Materials for Use in Glucose/O2 Biofuel Cells
(2014-04-21)
Tetramethylferrocene-modified linear(polyethylenimine) (FcMe4-C3-LPEI) was cross-linked with ethylene glycol diglycidyl ether (EGDGE) in the presence of glucose oxidase (GOx) on carbon electrodes to form enzymatic redox ...
Characterization and bioinformatic analysis of Pseudomonas aeruginosa condensins
(2019-12)
DNA is organized within chromosomes not only to permit a large amount of DNA to occupy a very small space, but also to serve essential functional roles. Varied levels of organization enable proper DNA replication, repair, ...
Heme and Hemoglobin Transport Systems of Listeria monocytogenes
(2010)
Heme (Hn) is an important iron source for Listeria monocytogenes, an intracellular pathogen that causes listeriosis. I characterized listerial Hn acquisition by two Fur-regulated genetic systems: the hup region that produces ...
Development of phage display-derived targeted cancer therapy and net-work scaffold for 3D cancer cell culture
(2018-12-14)
Precision medicine emphasizes the patient-specific formulation for treating diseases, especially cancer. For targeted cancer treatment, however, since the expression level of tumor receptors on each patient varies even for ...
MEASURING RATE CONSTANTS FOR THE REACTION OF HYPOCHLOROUS ACID AND BIOLOGICALLY RELEVANT MOLECULES
(2012)
Hypochlorous acid (HOCl) is a neutrophil-derived oxidant that is used to kill invading pathogens. Since HOCl reacts indiscriminately with biological molecules, such as amino acids, excess or misplaced production of HOCl ...