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Now showing items 81-90 of 104
Discovery of the molecular interactions mediating malaria transmission in the mosquito midgut
(2017)
Malaria is a worldwide health problem that affects two thirds of the world population and kills approximately one million people annually. Infecting Anopheline mosquitoes is the essential step for malaria transmission. ...
BIOLOGICAL IMPLICATIONS OF THE REACTIONS OF THIOCYANATE (SCN
(2011)
Hypochlorous acid (HOCl) is one of the major neutrophil-derived oxidants used to kill invading pathogens. However, excess or misplaced production of HOCl can damage host tissue as it reacts indiscriminately with biological ...
Branched polyethylenimine re-sensitizes methicillin-resistant Staphylococcus aureus to beta-lactam antibioitics through a novel mechanism of action
(2018)
Methicillin-resistant Staphylococcus aureus (MRSA) is a growing concern in the medical industry due to high morbidity and difficulty of treatment in infected patients. Conventional β-lactam antibiotics kill Staphylococcus ...
SYNTHESIS AND REDOX BEHAVIOR OF GROUP 8 METALLOPORPHYRINS AND RELATED COMPOUNDS
(2015)
This dissertation describes the Chemistry of Group 8 Metalloporphyrins and related compounds. Chapter one describes linkage isomerization in NOx-coordinated metal complexes with emphasis on Group 8 metals, and part of this ...
Investigations of Secondary Metabolites from Fungi: Isolation, Structure Elucidation, and Computational Studies
(2018-12-14)
Natural products have served as therapeutic agents in the treatment of many human health ailments for thousands of years. In order to find new therapeutic agents for future human health problems, those in the field of ...
M13 BACTERIOPHAGE-BASED POLYMERS, A PROMISING NEXT GENERATION OF BIOHYDROGEL
(2018-12-14)
Hydrogel has been considered a promising material for many biomedical applicational researches due to its unique properties. One such promising hydrogel is a peptide-based hydrogel due to its excellent biocompatibility and ...
Nuclear Magnetic Resonance Study of Nucleic Acid Tertiary Structures
(2011)
Ribonucleic acid (RNA) is ubiquitous to all organisms and a molecule that essential to all life forms. RNA is a versatile molecule with numerous cellular functions. With advances in nucleic acid sequencing, researchers ...
Mutational Analysis of Bacterial Condensins
(2011)
Genetic information is carried on chromosomes in all organisms and chromosome is at the center of all life processes. The chromosome must be properly folded to fit into the cells. Moreover, replication and segregation of ...
CONSTANT-pH MOLECULAR DYNAMICS SIMULATIONS: DEVELOPMENT AND APPLICATIONS
(2012)
Constant-pH molecular dynamics has recently emerged as a useful technique for studying the microscopic details underlying pH dependent properties of proteins. We further develop continuous constant-pH molecular dynamics ...
Roles of Unique Membrane Fusion Proteins
(2015-11)
One of the primary mechanisms of antibiotic resistance in bacteria stems from the expression of multicomponent efflux transporters, located in the membranes of both Gram-positive and Gram-negative bacteria. Although these ...