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TARGETED GENE DELIVERY TO MESENCHYMAL STEM CELLS USING NANOPARTICLES
(2016-05-13)
Stem cells hold great potential for the regenerative medicine and tissue engineering. Controlling the fate of stem cell in a reliable method still remains a problem. The strategies for directing the fate of stem cells ...
Synthesis, Purification and Assembly of Gold and Iron Oxide Nanoparticles
(2010)
The aims of the current research include developing new synthetic strategies to prepare structurally complex gold nanoparticles and new size sorting methods to separate nanoparticles of larger size, as well as studying the ...
IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES
(2012)
Type A influenza viruses cause seasonal epidemics and global pandemics driven by antigenic drift in the viral surface glycoproproteins, hemagglutinin (HA) and neuraminidase (NA). Each year in the United States more than ...
BACTERIAL FLAGELLA TEMPLATED SYNTHESIS OF HYBRID NANOMATERIALS BY BIOMIMETIC MINERALIZATION IN MILD CONDITIONS
(2011)
Biological template directed nanomaterials have unique properties. Under genetic control, they can specifically interact with other macromolecules or inorganics. Moreover, the biologically based materials are easily assembled ...
COPPER CHEMISTRY OF PYRIDYLALKYLBENZAMIDE LIGANDS: MODELING THE CUZ CENTER OF N2OR AND COORDINATION POLYMER CHEMISTRY
(2011)
In nature, the reduction of N2O to N2 is the terminal step of the denitrification process, which is catalyzed by nitrous oxide reductase (N2OR). The catalytic CuZ center was found to be a novel μ4-sulfide bridged ...
Interaction of Metal Ions with the Polyanionic Gram-Positive Cell Wall and the Effect of Antimicrobial Cationic Branched Polyethyleneimine on Metal Binding
(2014-12)
Metal binding is a known characteristic of the bacterial cell wall. Yet, the binding mechanisms and affinity constants are not fully understood. The cell wall of Gram-positive bacteria is characterized by a thick layer of ...
Nuclear Magnetic Resonance Study of Nucleic Acid Tertiary Structures
(2011)
Ribonucleic acid (RNA) is ubiquitous to all organisms and a molecule that essential to all life forms. RNA is a versatile molecule with numerous cellular functions. With advances in nucleic acid sequencing, researchers ...
Accessing Natural Products from Silent Biosynthetic Pathways Using Chemical Epigenetics
(2011)
Natural products have played a major role in the history of medicine. Despite this history, many view the area of natural products discovery to be tapped dry, thus the focus of drug development companies has shifted towards ...
Role of the outer membrane channel TolC in physiology of Escherichia coli
(2010)
TolC is a versatile, multifunctional protein and in Gram-negative bacteria such as E.coli, it has been shown to participate in several functions like drug efflux, toxin secretion and has also been demonstrated to be important ...
DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE
(2014)
Tumor specific drug delivery has become increasingly interesting in cancer therapy, as the use of chemotherapeutics is often limited due to severe side effects. Targeted chemotherapy for cancer treatment offers a great ...