Browsing OU - Dissertations by Author "Zgurskaya, Helen"
Now showing items 1-8 of 8
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Development of synthetic methodologies for N- to C-terminal cyclization of peptidomimetic small molecules and in silico and in vitro studies of the role of cyclization on antibacterial and antiviral activities
Avila, Quentin Paul (2022-05-13)Among the different mechanisms of resistance in Gram-negative bacteria, the permeability barrier of the outer membrane and efflux pumps represent a significant challenge to address as they synergize to reduce accumulation ... -
Differential Contributions of Outer Membrane Permeability and Active Efflux in Physiology and Drug Susceptibility of Gram-Negative Bacteria
Wolloscheck, David (2017-12-15)The increased frequency of antibiotic resistant bacterial isolates is of great concern for public health. It is currently estimated that infections caused by multidrug resistant pathogens will surpass cancer as a leading ... -
HARNESSING SMALL-MOLECULE PROTEIN STIMULATION TO DEVELOP NEW LEADS FOR RETINAL AND INFECTIOUS DISEASES
Dou, Xiaozheng (2020-07)This dissertation describes the development of new therapeutic leads for retinal (chapter 1-3) and infectious diseases (chapter 4). More than 40% of patients with retinal inflammatory diseases are refractory to the standard ... -
THE LIGAND BINDING PROPERTIES OF THE OXYSTEROL-BINDING PROTEIN FAMILY SUBFAMILY-I
Nunez, Juan (2018-12-14)The oxysterol-binding protein/OSBP-related proteins (OSBP/ORPs) are a family of proteins conserved in all eukaryotes that have complex biological activities connected to lipid transport and lipid regulation. OSBP is ... -
Mining Microbial Communities: Exploring Symbiotic Bacteria as a Source of New Natural Products
Theodore, Christine M. (2013)As ubiquitous inhabitants of Earth, bacteria represent a diverse resource in the search for new natural products. In order for the field of natural products to progress, new and exciting sources of biodiversity must be ... -
Purification, Mechanism, and Biochemical Interactions of the Essential Mycolic Acid Transporters MmpL3 from Mycobacterium tuberculosis, and CmpL1 from Corynebacterium glutamicum.
Stevens, Casey (2020-06)The Corynebacterium – Mycobacterium – Nocardia family (CMN family) are a subset group of actinomycetes which are characterized as acid-fast, Gram-positive species. Many members of the CMN family are causative agents of ... -
Roles of Unique Membrane Fusion Proteins
Nickels, Logan (2015-11)One of the primary mechanisms of antibiotic resistance in bacteria stems from the expression of multicomponent efflux transporters, located in the membranes of both Gram-positive and Gram-negative bacteria. Although these ... -
Stressed Out: Resistance-nodulation-division (RND) and Major Facilitator Superfamily (MFS) Efflux Pump Mediated Survival Strategies of Acinetobacter baumannii
Olvera, Marcela (2024-05-11)Originally discovered in soil microbial communities, reports of genus Acinetobacter associated infections started to increase around 1977 and continued to climb to frightening heights for the next 20 years resulting in ...