Browsing OU - Dissertations by Author "Zgurskaya, Elena"
Now showing items 1-11 of 11
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THE BIOCHEMICAL CHARACTERIZATION OF TWO PHOSPHORELAY SIGNALING PROTEINS: YPD1 HOMOLOGS FROM SACCHAROMYCES CEREVISIAE AND CRYPTOCOCCUS NEOFORMANS
Kennedy, Emily (2016-08)Histidine-to-aspartate multi-step phosphorelay systems are used extensively by eukaryotes and bacteria to sense and respond to changes in their external environment and to control the regulation of crucial biological ... -
Characterization and bioinformatic analysis of Pseudomonas aeruginosa condensins
Clevenger, April (2019-12)DNA is organized within chromosomes not only to permit a large amount of DNA to occupy a very small space, but also to serve essential functional roles. Varied levels of organization enable proper DNA replication, repair, ... -
Chemical Biology of Chromosome Segregation in Pseudomonas aeruginosa
Ajmal, Sidra (2024-05-10)Chromosome duplication and cell division are two critical events of a cell’s life cycle that occur with high precision across diverse environmental conditions. Inheriting a single copy of a chromosome by each daughter cell ... -
Chromosome Organization and Segregation in Pseudomonas Aeruginosa
Bhowmik, Bijit Kumar (2017-12)The faithful propagation of genetic information from a mother to its progeny is one of the most fundamental aspects of life. Encoding the entirety of an organisms' genetic information onto chromosomes poses a unique set ... -
A COMPUTATIONAL APPROACH FOR ACCESSING PHOSPHORYLATED RESPONSE REGULATOR CONFORMATIONS AND SIGNALING COMPLEXES INVOLVING THE FUNGAL PHOSPHORELAY PROTEIN YPD1
Foster, Clay (2016-08)Two-component signaling is the primary means by which bacteria, archaea and certain eukaryotes sense and respond to their environments. Signal transfer proceeds through sequential His-to-Asp phosphorylation of upstream ... -
Detailed analysis of protein-DNA interactions driving type II-A CRISPR adaptation
Van Orden, Mason (2020-08)CRISPR-Cas is an adaptive immune system that protects prokaryotes against foreign nucleic acids. Prokaryotes gain immunity by acquiring short pieces of the invading nucleic acid, termed prespacers, and inserting them into ... -
Development of phage display-derived targeted cancer therapy and net-work scaffold for 3D cancer cell culture
Qu, Xuewei (2018-12-14)Precision medicine emphasizes the patient-specific formulation for treating diseases, especially cancer. For targeted cancer treatment, however, since the expression level of tumor receptors on each patient varies even for ... -
Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps
Ntreh, Abigail (2016-08)Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of ... -
MULTISCALE RESPONSES TO PERTURBATION IN THE CONTEXT OF A HIGHLY CONTAMINATED FIELD SITE
Michael, Jonathan (2024-05-10)Microbes and microbial communities are ubiquitous in the environment and responsible for the cycling of carbon, sulfur, nitrogen, phosphorous, and more, while also being subject to variable conditions ranging from seasonal ... -
Protein engineering of Cas9 for safer genome tools, and phylogenetic analysis of Coronavirus spike protein for efficient antiviral targets
Newsom, Sydney (2022-12-16)Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins are adaptive immune systems that protect bacteria and archaea from mobile genetic elements. These systems have been ... -
STRUCTURAL AND MUTAGENESIS STUDIES OF THE YEAST PHOSPHORELAY SIGNALING PROTEINS YPD1 AND SSK1
Branscum, Katie (2015-12)His-Asp signaling systems are ubiquitous in bacteria, archaea, and certain plants and fungi. Little structural information is known about the protein-protein interactions within these signaling pathways, leaving an ...