Browsing OU - Dissertations by Author "Yang, Zhibo"
Now showing items 1-20 of 33
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The Advancement of Narrow Open Tubular Liquid Chromatography
Xiang, Piliang (2021-12-17)Open tubular columns are primarily used in gas chromatography, and they were regarded as the best choice to achieve high separation efficiency in gas chromatography. Substances diffuse much slower in liquids than in gases. ... -
Advancement of Natural Products: Optimization of Instrumentation and Examples of their Application to the Isolation of New Compounds
Mattes, Allison (2019)The world of natural products has a long rich history dating back thousands of years and was the origin of medicine as we know it. Advancements in the field of natural products can be seen not only in the isolation of new ... -
ANTIBIOTIC COMBINATION THERAPY AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS BIOFILMS AND BROADENING ANTIBIOTIC SPECTRUM USING POLYETHYLENIMINE
Lam, Anh (2020-07)Antibiotic resistance (AR) is a serious growing threat around the globe. There has been no new antibiotic class developed in the past 30 years, while antibiotic-resistant superbugs are emerging everywhere and becoming more ... -
Application of untargeted metabolomics techniques based on LC-MS/MS to parasitic diseases and drug development
Lesani, Mahbobeh (2023-08-04)Metabolites are small chemical molecules less than 1500 Da such as carbohydrates, lipids, and amino acids that provide different functions in organisms. These metabolites are the products of host metabolism or received ... -
BACTERIOPHAGE NANOFIBERS ENABLED NANOSTRUCTURES AND TARGET-RECOGNITION FOR BIO-APPLICATIONS
Xu, Hong (2015)Nanostructure is an object system that has dimensions on the nanoscale, i.e. between 0.1 and 100 nanometers. It includes nanotextured surface, nanotube, nanorod, nanofilament, nanoparticle, etc. The field of nanostructure ... -
Bioactive Molecules Detection and Identification in Complex Biological Systems through Activity-Based Metabolomics and Proteomics
Ma, Hongyan (2020-07)The detection and identification of bioactive molecules (e.g. therapeutic small-molecule lead compounds, functional proteins) from complex mixtures is often a critical step in various biochemical and biomedical research ... -
BIONANOFIBER-BASED NANOSTRUCTURE FABRICATION AND APPLICATIONS
Wang, Lin (2017-12)Among various strategies for the synthesis and assembly of nano-scaled structures, bio-templating is an efficient method due to the unique physical and chemical properties of the template bionanomaterials, thus has experienced ... -
Capillary-based analytical technique developments for analysis of bio-sample
Chen, Huang (2017-05)Analytical chemistry plays a significant role in bioscience research. Bio-samples, such as DNA and proteins, are often used for identification purpose or disease related research. Analyzing a biological sample typically ... -
Chemical Modeling of Unstable Intermediates in Heme-mediated NOx Biology
Abucayon, Erwin (2017-05-12)This dissertation describes the preparation, characterization, and reactivity of several critical unstable intermediates of relevance to the global N-cycle. Their spectroscopic signatures and chemical reactivities were ... -
DEVELOPING ELECTROOSMOTIC-PUMP-BASED MINIATURIZED DEVICES: TOWARD A LIQUID CHROMATOGRAPHY CARTRIDGE COUPLED WITH MASS SPECTROMETER AND A SUB-PICOLITER PIPETTOR FOR SINGLE CELL SURGERY
Chen, Apeng (2017-06)There has been increasing interest on miniaturizing high performance liquid chromatography (HPLC), since it can reduce the costs of instrument manufacturing and perform onsite analysis. The electroosmotic pump (EOP) is one ... -
DEVELOPMENT AND APPLICATION OF SINGLE CELL MASS SPECTROMETRY TECHNIQUES FOR NON-ADHERENT CELL ANALYSIS
Zhu, Yanlin (2020-07)Mass spectrometry (MS) analysis of biological samples is traditionally carried out using extractions from large populations of cells, concealing the information from individual cells. In contrast, the drawbacks of traditional ... -
DEVELOPMENT OF BENCHTOP CAPILLARY-BASED ANALYTICAL INSTRUMENTS FOR CHROMATOGRAPHIC SEPARATION AND DETECTION
Lynch, Kyle (2018-05-01)Point-of-Care (POC) analysis in recent years has driven the need for the miniaturization of chemistry instruments in the analytical field. One such instrument class involves chromatographic systems for the separation and ... -
DEVELOPMENTS AND APPLICATIONS OF HIGH-THROUGHPUT TOP-DOWN PROTEOMICS
Wang, Zhe (2019)Emerging technologies for liquid chromatography (LC) separations and mass spectrometry (MS) have dramatically improved the throughput of top-down proteomics, which has allowed the identification of thousands of intact ... -
Discovery of the molecular interactions mediating malaria transmission in the mosquito midgut
Zhang, Genwei (2017)Malaria is a worldwide health problem that affects two thirds of the world population and kills approximately one million people annually. Infecting Anopheline mosquitoes is the essential step for malaria transmission. ... -
Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis
Nguyen, Tra (2023-12-15)Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms. This ... -
THE IMPACT OF ADDITIVES IN ACIDIC ZEOLITES ON HYDROCARBON-BASED REACTIONS
Abdul Rahman, Nabihan (2024-05)The incorporation of metal additives into zeolites has allowed a much higher degree of zeolite tunability, including altering the original active sites, introducing new active sites, modifying pore structures, and introducing ... -
Interaction of Metal Ions with the Polyanionic Gram-Positive Cell Wall and the Effect of Antimicrobial Cationic Branched Polyethyleneimine on Metal Binding
Thomas, Kieth (2014-12)Metal binding is a known characteristic of the bacterial cell wall. Yet, the binding mechanisms and affinity constants are not fully understood. The cell wall of Gram-positive bacteria is characterized by a thick layer of ... -
M13 BACTERIOPHAGE-BASED POLYMERS, A PROMISING NEXT GENERATION OF BIOHYDROGEL
Cho, James (2018-12-14)Hydrogel has been considered a promising material for many biomedical applicational researches due to its unique properties. One such promising hydrogel is a peptide-based hydrogel due to its excellent biocompatibility and ... -
Mass spectrometry-based metabolomics analysis of Chagas disease models
Liu, Zongyuan (2024-05-10)Chagas disease (CD) is a neglected tropical disease which is caused by the parasite Trypanosoma cruzi. Approximately 6 to 7 million people in the world are infected with T. cruzi. The symptoms at the acute phase are mild ... -
METABOLOMIC ANALYSIS OF LIVE SINGLE CELLS AND SPHEROID SECRETIONS USING MASS SPECTROMETRY: TOWARDS UNDERSTANDING OF CELLULAR METABOLISM
Sun, Mei (2019-05-10)This dissertation describes the single cell metabolomics analysis and microscale extracellular metabolites analysis using the Single-probe mass spectrometry (MS) techniques. Chapter one summarizes the current ...