Browsing OU - Dissertations by Author "O'Rear, Edgar"
Now showing items 1-20 of 21
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Advanced Turbulence Modeling Strategies Within the Hybrid RANS-LES Framework
Jamal, Tausif (2020)Reynolds Averaged Navier-Stokes (RANS) models still represent the most common turbulence modeling technique used in Computational Fluid Dynamics (CFD) today. RANS models are preferred primarily due to their relatively low ... -
CHARACTERIZATION OF POLYETHOXYLATED ALKYL PHENOLS WITH A HIGH DEGREE OF ETHOXYLATION AT THE SOLID-LIQUID INTERFACE
Baker, Danielle Kimberly (2016-05)Fully characterizing the behavior of a surfactant, from the mechanism of adsorption to the formation of micelles, is vital when taking the surfactant out of the lab and into the real world. The critical micelle concentration, ... -
Chemoenzymatic Transformations of Indole and Azaindole Containing Natural Product Analogs Using Promiscuous Prenyltransferases
Gardner, Eric (2021-12-17)The overall aim of my work was to expand the practical utility of prenyltransferase-based biocatalysis as a tool in organic synthesis, natural product diversification, and drug discovery efforts. Aromatic prenyltransferases ... -
Computational Investigation of the Behavior of Nanoparticles and Surfactants at the Oil-Water Interface
Vu, Tuan Viet (2021-12)Surfactants and nanoparticles (NPs) are commonly used to stabilize emulsions, which have found applications in different areas. The fundamental understanding of the behavior of surfactants and NPs adsorbed at the oil-water ... -
COMPUTATIONAL INVESTIGATION OF TURBULENT BLOOD FLOW AND HEMOLYSIS IN BIOMEDICAL DEVICES
Ozturk, Mesude (2015-12-18)Turbulent blood flow in medical devices contributes to blood trauma, yet the exact mechanism(s) have not been fully elucidated. Local turbulent stresses, viscous stresses, and the rate of dissipation of the turbulent kinetic ... -
Concise synthesis methods to aminosterols and sterol N-glycosides for the development of new OSW-1-derived scaffolds
Malinky, Cori (2020-05-08)Abstract The cholestane glycoside natural product compound OSW-1 has both broad spectrum antiviral activity and potent antiproliferative activity. OSW-1 is a high affinity ligand of both oxysterol-binding protein (OSBP) ... -
Development of Contrast Agents for Optoacoustic Imaging
MacCuaig, William (2023-12-15)Optoacoustic imaging is an emerging modality with inherent advantages relevant for clinical use. Following excitation of optoacoustic contrast agents with ultrashort (~10 ns) pulses of near-infrared light, thermoelastic ... -
THE EFFECTS OF RANDOM AND CONTROLLED LATERAL CONFINEMENT ON SURFACTANT ADSORPTION
Hamon, Joshua Jacob (2018-07-31)Abstract The effects of temperature and surface roughness on the mass and viscoelasticity of an adsorbed surfactant layer were monitored using the quartz crystal microbalance with dissipation (QCM-D). Adsorption isotherms ... -
Electromyographic Measurement of the Chinchilla Middle Ear Muscle Reflex Elicited by Acoustic or Blast Stimuli
Yokell, Zachary (2019-05-10)Hearing damage is a widespread problem that can cause social isolation and reductions in quality of life. A wide range of conditions including extended exposure to noise or near-instantaneous exposure to blast overpressure ... -
Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs
Nguyen, Hoai (2015)Cardiovascular diseases, including acute myocardial infarction, stroke, peripheral arterial diseases, and pulmonary embolism, are the most common and growing cause of morbidity and mortality in the United States. Early ... -
Enzymatic and non-enzymatic bioanodes: novel materials for glucose oxidase and polyviologen biosensors and biofuel cells
Wilson, Stephen (2023-12-15)A fundamental study of the interaction of iodide and glucose oxidase (GOx) was carried out, showing that the iodide acts as a direct mediator with GOx in enzymatic glucose biosensors. This direct mediation may be happening ... -
Flame Synthesis of Tungsten/Molybdenum Oxide Nanoscale Heterostructures with Complex Physical Morphologies
Cuello Jimenez, Walmy (2023-05-12)The focus of this dissertation is to investigate the synthesis of crystalline transition metal oxide (TMO) structures in a counter-flow diffusion flame. This thesis examines the underlying mechanisms for the flame synthesis ... -
Investigation of Flow through Complicated Microfluidic Devices and over Micropatterned Surfaces using Computational Fluid Dynamics
Heck, Margaret (2015-12)Computational fluid dynamics is used to study two distinct areas of engineering interest: microfluidic systems involving superhydrophobic surfaces and blood pumps. Superhydrophobic surfaces, which can induce slip at ... -
Investigation of Flow through Complicated Microfluidic Devices and over Micropatterned Surfaces using Computational Fluid Dynamics
Heck, Margaret (2015-12)Computational fluid dynamics is used to study two distinct areas of engineering interest: microfluidic systems involving superhydrophobic surfaces and blood pumps. Superhydrophobic surfaces, which can induce slip at ... -
Mechanisms in determining erythrocyte senescence and membrane damage caused by supra-physiological flow conditions
Buerck, James (2020-12)Incidence of cardiovascular diseases (CVDs) is growing more prevalent in today’s society as a result of changes of three basic factors: the increasing age of the general population, declines in mortality as a result of ... -
Moisture-Induced Damage Characterization of Asphalt Mixes: A Chemical, Thermodynamic and Mechanistic Approach
Ali, Syed Ashik (2021-05)Moisture-induced damage is one of the major distresses which leads to the deterioration of mechanical properties of asphalt mixes and failure of asphalt pavements. Evaluation of the moisture-induced damage potential is a ... -
Phosphatidylserine Targeted Biotechnology Agents for Cancer
Virani, Needa (2017-08-16)Cancer is a highly mutating disease that quickly develops resistance to chemotherapies and has a high rate of relapse. If detected early, the survival rate is greater than 90% for most cancers; however if diagnosed during ... -
Semiotic and narrative elements in Franz Liszt’s Vallée d’Obermann
Roy, Omar (2020-05)Liszt’s Vallée d’Obermann, like many piano works from his Années de Pèlerinage, is explicitly linked to extramusical sources. In this case the inspiration is ostensibly Étienne Pivert de Senancour’s novel Obermann, from ... -
Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors
Gardner, Jessica Jeanora Hayes (2022-05-13)The overall aim of this work is to contribute to molecular design strategies for early lead development while probing structure-activity relationships via the design and synthesis of small molecules. This dissertation will ... -
Strategies to Reduce the Foreign Body Response to Cortical Neural Interfaces
Markwardt, Neil (2013-12)Cortical neural interfaces offer unique capabilities to researchers and physicians, opening doors to superior understanding and treatment of a host of processes and diseases in the central nervous system. One of modern ...