Browsing OU - Dissertations by Author "Acar, Handan"
Now showing items 1-11 of 11
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Characterization of the protein-protein interactions of the type-II toxin-antitoxin system ParDE1 from Pseudomonas aeruginosa
Snead, Kevin (2023-05-12)The emergence of multidrug-resistant bacteria has led to an ever-growing antibiotic resistance crisis. To combat this growing crisis, new strategies for controlling bacterial cell growth must be developed. An underdeveloped ... -
Development of a Conductive Bioink Hydrogel for Translational Spinal Cord Regeneration
Kiyotake, Emi (2020-07-30)Spinal cord injury (SCI) patients rarely recover full functionality with current clinical treatments. There are two approaches for developing treatments for SCI: 1) rehabilitation strategies and 2) regenerative medicine ... -
Development of Patient-Specific Shape Memory Polymer Foams for the Treatment of Intracranial Aneurysms
Pineda Castillo, Sergio Andres (2023-05-12)The objectives of this research include: (1) designing an electrically conductive shape memory polymer (SMP) material, (2) developing a method for the systematic fabrication of SMPs with complex three-dimensional geometries ... -
Engineering a peptide-based tool for biomedical applications
Hamsici, Seren (2022-12-16)Numerous technological and scientific advancements have been developed by the structural organization and functional capabilities of natural materials. A field known as "biomaterials" focuses on adapting engineering concepts ... -
Establishing elemental analysis to quantify nanoscale interactions at single nanoparticle and single cell levels
Donahue, Nathan (2021-12-17)For over two decades, nanoscale materials have been utilized as diagnostics and therapeutics. The successful clinical implementation of these platforms depends on well-defined physicochemical properties. However, such ... -
Improving Quantification of Nanoscale Interactions by Engineering Monodisperse Gold Nanoparticles
Frickenstein, Alex (2023-08-04)Mechanisms of nanoparticle-cell interactions are dependent upon the size of the administered nanoparticles. At pre-clinical and clinical levels, precise control over the size and monodispersity of nanoparticles is required ... -
Investigations of secondary metabolites from fungi: isolation, structure elucidation, and semi-synthetic studies
Peramuna, Peramunu (2022-12-16)Trichomoniasis, caused by Trichomonas vaginalis remains a worldwide threat, afflicting an astonishing 3.9% of the world’s population. This parasite is recognized as a cause of vaginitis and can result in serious health ... -
A novel polysaccharide-based surface engineering strategy for nanomedicines
Yang, Wen (2022-08-04)This dissertation presents the development and evaluation of a novel polysaccharide-based surface engineering strategy for nanomedicines. Chapter one summaries the current status of nanoparticle toxicology. Nanoparticles ... -
Peptide Aggregation Induced Immunogenic Cell Death
Gunay, Gokhan (2022-12-16)Cell death is an inevitable biological outcome, every living thing dies. However, how cells die is an important question and ultimately is decisive in homeostasis and disease progression. Immune system is in the center of ... -
Synthetic chondroinductive biomaterial for hyaline cartilage regeneration
Ajeeb, Boushra (2024-05-10)Avascularity, low cell count, and low proliferative potential constitute the triad that defines the limited self-regenerative potential of articular cartilage. Consequently, the repair of articular cartilage defects presents ... -
The tricuspid valve: mechanics, microstructure, modeling, and simulation
Laurence, Devin (2022-08)The objectives of this research include: (1) experimentally characterizing the multi-scale properties of the tricuspid valve (TV) leaflets, (2) linking the mechanical and microstructural properties of the TV leaflets to ...