Browsing OSU Theses by Subject "c-terminal domain binding site"
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HSP90 C-terminal Domain Binding Site For Novobiocin and Related Coumarins
(Oklahoma State University, 2010-05-01)Heat shock protein 90 (Hsp90) is a highly conserved, eukaryotic, molecular chaperone which stabilizes an assortment of oncogenic proteins. Currently, novobiocin and related coumarins are being developed into higher affinity ...