Browsing OSU Theses by Author "Fahlenkamp, Heather"
Now showing items 1-19 of 19
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Biophysical effects of matrices on cellular colonization
Iyer, Pooja (Oklahoma State University, 2009-07-01)Chitosan-gelatin 3D matrices exhibit better cell viability, and significantly better functionality than the other structures which included tissue culture plastic, 2D structures, hydrogel structures and chitosan 3D structures. ... -
Concept of Viscous Heating to Reinvent the Toilet
Islam, MD. Waliul (Oklahoma State University, 2013-12-01)Highly viscous substances, such as feces, produce significant heat when layer deformation occurs. We describe the use of viscous heating to destroy disease-causing microorganisms and whipworms in feces using a small amount ... -
Design of an Axial Flow Bioreactor for Tissue Regeneration
Raja Bhaskar, Prasana (Oklahoma State University, 2012-05-01)Modeling of bioreactors using Computational Fluid Dynamics (CFD) tools have been adapted for several bioreactor configurations such as flow-through, parallel-flow, and rotary. In this study, modeling was mainly performed ... -
Designing a Bioreactor for Regenerating High Aspect Ratio Tissues
Devarapalli, Mamatha (Oklahoma State University, 2008-12-01)Many tissues have a high aspect ratio (large surface area relative to the thickness of the matrix) and contain multiple cell types. Effect of flow-through configuration within these systems has not been studied. In these ... -
Development of a feeding strategy for a fed-batch culture of a monoclonal antibody-producing Agarabi CHO cell line
Hanna, Abanoub (2021-07)Animal cell culture is the most extensively used platform for producing novel, recombinant DNA-based therapeutics as these cells have the required machinery to make human-like post-translational modifications. In 2017, ... -
Development of a tissue-engineered eye model to test drug delivery systems
Oswalt, Katie (2021-12)One of the leading causes of blindness is diabetic retinopathy, a disease that affects the posterior segment of the eye. Injections are commonly used to treat diabetic retinopathy, but they can lead to discomfort and low ... -
Effect of Glycated Albumin and Shear Stress on Endothelial Cell Functions
Maria, Zahra (Oklahoma State University, 2011-07-01)Our goal was to evaluate the combined effect of albumin glycation extent and physiological shear loading on endothelial cell (EC) functions. Cultured ECs were incubated with glycated or non-glycated albumin (2, 6 or 8 weeks ... -
Effects of Physiological Variables on Growth of Organohalide Respirers
Boothe, Melissa Anne (2015/12/1)There is a group of bacteria that is capable of the reductive dechlorination of chlorinated compounds, such as PCEs, by energetically using the chlorines in the compounds as terminal electron acceptors when oxygen is not ... -
Evaluation of Cell Penetrating Peptide/Adenovirus Particles for Transduction of Car-negative Cells
Nigatu, Adane Sebsibe (Oklahoma State University, 2012-12-01)Adenovirus (Ad) is a promising gene therapy vector and is used currently in more than 23% of clinical gene therapy trials. The viral vector, however, has drawbacks such as immunogenicity, promiscuous tropism, and the ... -
Evaluation of Chemical Processes for Sustainable Optimization
Samli, Afshan Ibrahim (Oklahoma State University, 2011-05-01)Increasing concerns over global climate change due to greater amounts of greenhouse gases in the atmosphere or ozone depletion etc. are leading engineers to address `environmental' impacts of industrial processes. Additionally, ... -
Ex Vivo Generation of Dendritic Cells Within a Vascular Bioreactor
Williamson, Patrick (2019-05)Dendritic cells (DCs) play a prime role in the activation and control of the immune system and have promising potential in the treatment of cancer, viral infection, autoimmune diseases and transplantation rejection. DCs ... -
Farm Ethanol Dewatering: Detailed Design Of Distillation Unit
Mukherjee, Anuradha (Oklahoma State University, 2009-12-01)Sweet sorghum offers a range of advantages due to its low water input, high carbohydrate yield and drought tolerant characteristics. The team at the School of Bio-systems & Agricultural Engineering at Oklahoma State ... -
Formation Of Concentration Gradients Of Monocyte Chemoattractant Protein-1 in a Collagen Matrix
Leemasawatdigul, Krisada (Oklahoma State University, 2010-07-01)This research project determined the formation of the static and soluble concentration gradients of monocyte chemoattractant protein-1 (MCP-1) in a collagen matrix using a 3D in vitro vascular tissue model. Stability of ... -
High-temperature Ethane Dehydrogenation in Microporous Zeolite Membrane Reactor: Effect of Operating Conditions
Dangwal, Shailesh Singh (2017-07-01)Ethylene is the largest base chemical for the chemical industry and produced either by cracking or dehydrogenation of light alkanes. The increasing demand for ethylene has stimulated substantial research into the development ... -
Incorporation of the Generalized Tsk Models in Model Predictive Control
Chen, Haoxian (Oklahoma State University, 2011-12-01)The generalized TSK (GTSK) modeling approach is proved to provide accurate model prediction and to alleviate the computational burden. The scope of this study is to incorporate the GTSK models in the nonlinear model ... -
Multiphase Modeling of Monocyte Migration and Differentiation in a Flow Bioreactor System: An In-Silico Study
Kozak, Max Clemens (2019-05-01)The objective of this study was to model monocyte migration and differentiation into dendritic cells under a variety of conditions in a novel designed plate bioreactor with flow using Computational Fluid Dynamics (CFD) ... -
Poly(L-lysine)-grafted-poly(ethylene glycol) nanoparticles for delivery of proteins: Effects of stimulus-responsive crosslinking and tunable millifluidic assembly
Seaberg, Joshua (2020-05)Polymeric nanoparticles have drawn attention for their ability to enhance the efficacy of therapeutic proteins through reduced immunogenicity and extended circulation time. Nevertheless, nanoparticle drug delivery systems ... -
Process Design and Simulation for Extraction of Milk Fat Using Liquid Propane
Byluppala, Harita (Oklahoma State University, 2010-12-01)Numerous studies have been conducted to increase the utilization of milk by fractionating the fat. This work examines the use of liquid propane for extraction of lipids from bovine milk. Aspen Plus(TM), a commercial process ... -
Separation of Resin Types in Mixed Bed Ion Exchange Columns
Gopalakrishnan, Bharathwaj (Oklahoma State University, 2011-05-01)Resin separation is a vital step prior to regeneration of Ion Exchange resins. The degree of separation determines the extent of sodium and sulfate or chloride into the system from caustic and acid regenerants, respectively. ...