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Defined interactions of protein kinases with Hsp90 and Cdc37
(2005-12)
Scope and Method of Study: Protein kinases function to transduce the countless number of signals that allow a cell to grow and adapt to its environment. A significant number of protein kinases require assistance in being ...
Studies of Hsp90 function on signal transduction molecules in C2C12 cells and effects of novobiocin on Hsp90 conformation and function and mechanism of regulation of heme-regulated eIF2alpha kinase by gas molecules
(2004-12)
Scope and Method of Study: The purpose of this study was to investigate: the function of Hsp90 on signal transduction pathways required for C2C12 myoblast differentiation; to characterize the effect of the Hsp90-inhibitor ...
Functional modulation of DBC2 by the Hsp90 chaperone machine
(2012-05)
Scope and Method of Study: This study involved looking at various mechanistic associations of the tumor suppressor DBC2 with the Hsp90 chaperone machine. Along with aspects of functional relationships of co-chaperone and ...