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Epithelial-to-mesenchymal transition and fibroblast differentiation in idiopathic pulmonary fibrosis
(2015-12)
The aim of the present study is to explore the molecular mechanisms of epithelial-to-mesenchymal transition and fibroblast differentiation during the pathogenesis of idiopathic pulmonary fibrosis.
Ehrlichia spp. of dogs: Risk of infection, persistence of rickettsemia, and impact on reinfection
(2015-05)
The research presented in this dissertation was conducted to further understanding of Ehrlichia spp. infections in dogs in the U.S. and Haiti. In chapter 3, to determine the risk of infection posed to dogs exposed to ticks ...
Effect of diabetes on the regulation of placenta growth factor
(2015-07)
Cardiovascular disease is the number one cause of death worldwide, representing 31% of all global deaths. Among them, over 14 million are due to ischemic coronary heart disease and stroke. Additionally, peripheral artery ...
Assessment of the therapeutic effects of OKN-007 in rodent glioma models using advanced MRI techniques
(2015-05)
Glioblastoma is a malignant grade IV glioma with a poor prognosis in humans. New therapeutics are desperately required. The nitrone OKN-007 (2,4-disulfophenyl-PBN) has demonstrated effective anti-glioma properties in several ...
Mechanisms of beta cell dysfunction and application of GLP-1 mimetics in feline diabetes mellitus
(2015-12)
The causes of beta cell dysfunction and loss in feline diabetes mellitus (FDM) are incompletely understood. Potential causes of beta cell failure include amyloid accumulation, oxidative stress, inflammatory cytokine ...
Regulation of placental growth factor by fluid shear stress in the vessel wall
(2015-07)
Arteriogenesis is the process by which mature arteries form from collateral arterioles after upstream arterial stenosis or occlusion. During collateral remodeling, monocytes are recruited to the vessel wall. Placental ...