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Virus detection in a metagenomic sequence dataset: Methods and applications
(2013-07)
Global trade of plant material has increased the introduction of foreign plant viruses in nations across the world. This has led to the need for increased abilities to detect plant viruses. Surveys assessing the viral ...
Proteomics fingerprints of AUY922 and 17-DMAG indicate common mechanisms of action for Hsp90 inhibitors
(2013-12)
In this work, we identified the proteomics fingerprint of the anti-cancer drug candidate AUY922 in Jurkat leukemia cells and compared AUY922's fingerprint to the proteomics fingerprints of flagship Hsp90 inhibitors 17-DMAG ...
Identification and characterization of natural compound inhibitors of the Hsp90 chaperone complex
(2013-07)
The 90 kDa Heat Shock Protein (Hsp90) has emerged as a major therapeutic target for a number of diseases, the most notable of which is cancer. Accordingly, many groups are attempting to develop small molecules that modulate ...