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Role of protein subunits in superoxide generation by the cytochrome bc1 complex from Rhodobacter sphaeroides
(2009-12)
Scope and Method of Study:
Method of enrichment of the endoplasmic reticulum and Golgi complex proteins from wheat seeds (Triticum aestivum) at different stages of growth
(2005-05)
Scope of study: Bread wheat (Triticum aestivum) is an important economic crop in the US and the world and its quality is related to storage protein. This study attempts to describe the proteins associated with the endoplasmic ...
Transduction of E2F-1 Tat fusion proteins into primary invasive ductal breast carcinoma cell lines and subsequent effects on gene transcription
(2007-05)
Scope and Method of Study: Breast carcinomas harbor specific genetic alterations that contribute to their immortalized state, including overexpression of telomerase and p53 tumor suppressor gene mutations. E2F-1 is a known ...
Defined interactions of protein kinases with Hsp90 and Cdc37
(2005-12)
Scope and Method of Study: Protein kinases function to transduce the countless number of signals that allow a cell to grow and adapt to its environment. A significant number of protein kinases require assistance in being ...
X-ray crystallographic studies of the cytochrome bc1 complex
(2006-12)
Scope and Method of Study: The purpose of this study was to enhance the understanding of the bc1 complex. The method used in this study is x-ray crystallography and protein crystallization.
Characterization of triacylglyceride lipase and mono- and diacylglycerol acyltransferases in Manduca sexta
(2014-07)
Triglyceride (TG) is the main form of lipid storage in the cell. The processes of hydrolysis and synthesis of TG play critical roles the lipid metabolism. Triglyceridelipase(TGL) is a major fat body lipase hydrolyzing TG ...
Development of oligonucleotide-based microarrays for the detection of plant viruses and the first characterization of a plant virus belonging to the family Totiviridae
(2010-12)
Scope and Method of Study: Ongoing studies for discovery of viral species in non-cultivated plants utilize several genomic approaches for systematic unbiased searches for viruses related to known viruses. Some of these ...
Structural and functional studies on vaccinia virus E3 protein
(2019-05)
E3 protein from vaccinia virus is a key host-range protein, which suppresses the innate antiviral immune response of the infected cells. In response to the viral infection, Protein Kinase R (PKR) of the host cell initiates ...
Characterizing mechanisms of potential inhibitors of the Hsp90 chaperone complex
(2023-05)
In this work, we characterized the effects of ten compounds reported to be inhibitors of the Hsp90 chaperone complex in Jurkat leukemia cells, and compared them to the N-terminal Hsp90 inhibitor AUY922. Our primary focus ...