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Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins
(2020-07)
Oxysterol-binding protein (OSBP) and the OSBP-related proteins (ORPs) comprise a family of lipid-binding proteins organized into 6 subfamilies in humans. ORP subfamily 1 consists of OSBP and its closest homolog, ORP4. OSBP ...
Concise synthesis methods to aminosterols and sterol N-glycosides for the development of new OSW-1-derived scaffolds
(2020-05-08)
Abstract
The cholestane glycoside natural product compound OSW-1 has both broad spectrum antiviral activity and potent antiproliferative activity. OSW-1 is a high affinity ligand of both oxysterol-binding protein (OSBP) ...
Purification, Mechanism, and Biochemical Interactions of the Essential Mycolic Acid Transporters MmpL3 from Mycobacterium tuberculosis, and CmpL1 from Corynebacterium glutamicum.
(2020-06)
The Corynebacterium – Mycobacterium – Nocardia family (CMN family) are a subset group of actinomycetes which are characterized as acid-fast, Gram-positive species. Many members of the CMN family are causative agents of ...