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Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins
(2020-07)
Oxysterol-binding protein (OSBP) and the OSBP-related proteins (ORPs) comprise a family of lipid-binding proteins organized into 6 subfamilies in humans. ORP subfamily 1 consists of OSBP and its closest homolog, ORP4. OSBP ...
Low-molecular-weight branched polyethylenimines: Multifunctional beta-lactam potentiators against resistant Gram-negative pathogens
(2022-05-13)
Antibiotic resistance is a simmering threat to the global public health system. Currently, it is estimated by the Centers for Disease Control and Prevention that at least 2.8 million people in the US get infected with ...
Characterization of the protein-protein interactions of the type-II toxin-antitoxin system ParDE1 from Pseudomonas aeruginosa
(2023-05-12)
The emergence of multidrug-resistant bacteria has led to an ever-growing antibiotic resistance crisis. To combat this growing crisis, new strategies for controlling bacterial cell growth must be developed. An underdeveloped ...
Design and Generation of Peptidomimetic ClpP Activator and N-Phenyl-1-Naphthylamine Libraries as Tools for Understanding Physicochemical Properties that Influence Gram-negative Accumulation
(2020-06)
Gram-negative bacteria pose a major threat to human health as they demonstrate low sensitivity to most antibiotics. This lack of sensitivity to antimicrobials is largely due to the amphipathic membrane architecture and ...
Concise synthesis methods to aminosterols and sterol N-glycosides for the development of new OSW-1-derived scaffolds
(2020-05-08)
Abstract
The cholestane glycoside natural product compound OSW-1 has both broad spectrum antiviral activity and potent antiproliferative activity. OSW-1 is a high affinity ligand of both oxysterol-binding protein (OSBP) ...
Purification, Mechanism, and Biochemical Interactions of the Essential Mycolic Acid Transporters MmpL3 from Mycobacterium tuberculosis, and CmpL1 from Corynebacterium glutamicum.
(2020-06)
The Corynebacterium – Mycobacterium – Nocardia family (CMN family) are a subset group of actinomycetes which are characterized as acid-fast, Gram-positive species. Many members of the CMN family are causative agents of ...
Characterization of a Sporulation Related Two-Component Signaling System in Clostridioides difficile
(2023-12-15)
Clostridioides difficile is a spore-forming anaerobic human pathogen, that is commonly associated with antibiotic therapy in adults. The disturbance of the gut microbiota, typically caused by antibiotics, allows for an ...