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Mechanisms of enzymes of the a-aminoadipate pathway: Homocitrate synthase from Thermus thermophilus and saccharopine dehydrogenase from Saccharomyces cerevisiae
(2011)
The &alpha-aminoadipate (AAA) pathway for lysine biosynthesis is nearly unique to higher fungi, including human and plant pathogens and euglenoids; an exception is the thermophilic bacterium Thermus thermophilus. . ...
ACTIVATION OF FUNGAL SILENT BIOSYTHETIC PATHWAYS BY EPIGENETIC MODIFICATION
(2011)
Natural products have played an important role as drug leads for different diseases. They provide unique structural cores with diverse biological activities. Because of the overuse of antibiotics many pathogens have developed ...
Accessing Natural Products from Silent Biosynthetic Pathways Using Chemical Epigenetics
(2011)
Natural products have played a major role in the history of medicine. Despite this history, many view the area of natural products discovery to be tapped dry, thus the focus of drug development companies has shifted towards ...