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Metabolite Profiling Of Experimental Cutaneous Leishmaniasis Lesions Demonstrates Significant Perturbations In Tissue Glycerophosphocholines
(2021-05-15)
Each year 700,000 to 1.2 million new cases of cutaneous leishmaniasis (CL) are reported and yet CL remains one of thirteen diseases classified as neglected tropical diseases (NTDs). Leishmania major is one of several ...
Ethical Priority of the Most Actionable System of Biomolecules: the Metabolome
(2019-10-23)
The metabolome is a system of small biomolecules (metabolites) and a direct result of human bioculture. Consequently, metabolomics is well poised to impact anthropological and biomedical research for the foreseeable future. ...
Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease
(2020-07-22)
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa, presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the mechanisms of gastrointestinal (GI) CD tissue tropism, we ...
Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies
(2021-10-26)
The success of natural product-based drug discovery is predicated on having chemical collections that offer broad coverage of metabolite diversity. We propose a simple set of tools combining genetic barcoding and metabolomics ...
Local Phenomena Shape Backyard Soil Metabolite Composition
(2020-02-29)
Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil ...
Liquid Chromatography-tandem mass spectrometry-based metabolite profiling in the hearts of germ-free and conventionally-raised mice
(2020-12-15)
The microbiota is the community of microorganisms living on and in a biological
system. It has shown to play a role in a broad range of medical conditions,
including cardiovascular diseases. Germ-free (GF) mice grew under ...