Browsing by Subject "iron homeostasis"

Now showing items 1-2 of 2

    • Enzymatic assessment of cells with distinct TP53 mutations 

      Kouplen, Kate; Hermann, Evan; Cardona, Cameron (Oklahoma State University, 2022-04-15)
      The p53 transcription factor, encoded by the human gene TP53, is the most commonly mutated gene in human cancers. Once the TP53 gene is mutated, p53 proteins not only lose their tumor suppression abilities but can also ...

    • Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis 

      Donegan, Rebecca K.; Fu, Yibo; Copeland, Jacqueline; Idga, Stanzin; Brown, Gabriel; Hale, Owen F.; Mitra, Avishek; Yang, Hui; Dailey, Harry A.; Niederweis, Michael; Jain, Paras; Reddi, Amit R. (American Society for Microbiology, 2022-10-26)
      Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...