Browsing by Subject "iron"
Now showing items 1-10 of 10
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Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis
(American Society for Microbiology, 2022-10-26)Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ... -
Heme and hemoglobin utilization by Mycobacterium tuberculosis
(Springer Nature, 2019-09-18)Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding protein DppA of the inner membrane Dpp ... -
Impact of ferroptosis induction on iron metabolism in cancer cells harboring TP53 mutations
(2020-12)The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer, but mutations in TP53 do not just result in loss of tumor suppressor function, they can also promote cancer progression by altering cellular ... -
Influence of HDAC inhibition on the maintanance of iron homeostasis and the acquisition of oncogenic phenotype in cancer cells
(2021-12)Epithelial-to-mesenchymal transition (EMT), an essential mechanism for development and wound healing, but in cancer it also mediates the progression and spread of aggressive tumors while increasing therapeutic resistance. ... -
The Influence of Iron Deficiency on Declarative, Procedural, and Working Memory
(2018-12-14)Previous research has found that iron deficiency (ID) is associated with deficits in cognition, including aspects of memory. However, little has been done to identify specific aspects of memory that are negatively affected, ... -
Mycobacteria, metals, and the macrophage
(Wiley, 2015-03)Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ... -
Novel approach to identify inhibitors of iron acquisition systems of Pseudomonas aeruginosa
(American Society for Microbiology, 2022-07-13)Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P. ... -
Novel Ca²⁺ sensor controlling iron uptake in Pseudomonas aeruginosa, a human pathogen
(Oklahoma State University, 2023-04-27)Pseudomonas aeruginosa is a Gram negative, opportunistic pathogen which causes a wide range of severe infections in humans. These infections are difficult to treat and, especially in the lungs of cystic fibrosis (CF) ... -
Response of Campylobacter jejuni to iron and hydrogen peroxide
(2004-12)Scope and Method of study: Iron affects the physiology of bacteria in two different ways: as a micronutrient for bacterial growth and as a catalyst for the formation of hydroxyl radicals. The present study reports the ... -
Zinc, Iron, Iodine and Cognitive Function of Women from Sidama Zone, Southern Ethiopia
(Oklahoma State University, 2010-07-01)The purpose of the study was examine zinc, iron, and iodine status and their relation to cognitive function of women. A cross-sectional convenience sample of 202 women from three adjoining subsistence farming communities ...