Browsing by Subject "heme"

Now showing items 1-5 of 5

    • Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis 

      Donegan, Rebecca K.; Fu, Yibo; Copeland, Jacqueline; Idga, Stanzin; Brown, Gabriel; Hale, Owen F.; Mitra, Avishek; Yang, Hui; Dailey, Harry A.; Niederweis, Michael; Jain, Paras; Reddi, Amit R. (American Society for Microbiology, 2022-10-26)
      Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...

    • Heme and hemoglobin utilization by Mycobacterium tuberculosis 

      Mitra, Avishek; Ko, Ying-Hui; Cingolani, Gino; Niederweis, Michael (Springer Nature, 2019-09-18)
      Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding protein DppA of the inner membrane Dpp ...

    • Heme Regulates Exocrine Peptidase Precursor Genes in Zebrafish 

      Han Wang; Qingchun Zhou; Jason W. Kesinger; Chad Norris; Cammi Valdez (Experimental Biology and Medicine, 2007-10-01)
      We previously determined that yquem harbors a mutation in the gene encoding uroporphyrinogen decarboxylase (UROD), the fifth enzyme in heme biosynthesis, and established zebrafish yquem (yqetp61) as a vertebrate model for ...

    • Novel approach to identify inhibitors of iron acquisition systems of Pseudomonas aeruginosa 

      Kannon, Mamie; Nebane, N. Miranda; Ruiz, Pedro; McKellip, Sara; Vinson, Paige N.; Mitra, Avishek (American Society for Microbiology, 2022-07-13)
      Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P. ...

    • Role of the Mycobacterium tuberculosis ESX-4 secretion system in heme iron utilization and pore formation by PPE proteins 

      Sankey, November; Merrick, Haley; Singh, Padam; Rogers, Janet; Reddi, Amit; Hartson, Steven D.; Mitra, Avishek (American Society for Microbiology, 2023-02-07)
      Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb ...