Browsing by Subject "elephant shark"

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    • ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1 

      Busca, Roser; Christen, Richard; Lovern, Matthew; Clifford, Alexander M.; Yue, Jia-Xing; Goss, Greg G.; Pouyssegur, Jacques; Lenormand, Philippe (BioMed Central, 2015-09-03)
      Background: The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ...