Browsing by Subject "cancer"
Now showing items 1-20 of 22
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Apoptotic and bioenergetic changes in pancreatic cells after exposure to individual toxicants and their mixtures
(2020-12)Pancreatic cancer has one of the worst fatality rates in oncology. Despite advances in treatment and recovery rates for other cancers, pancreatic cancer's lack of early symptomology culminates in a dismal five-year survival ... -
Demographics of individuals refusing cancer treatment and reported pain compared to those in treatment: An analysis of the 2017-2020 Behavioral Risk Factor Surveillance System
(Oklahoma State University Center for Health Sciences, 2023-02-17)Background: More than 1.6 million people are diagnosed with cancer each year.1 Despite the different treatment options available for cancer, many individuals refuse treatment for various reasons. However, there is little ... -
Development of Targeted Liposomal Formulation Approaches for Enhanced Colorectal Cancer Therapy
(2019-05)Colorectal cancer (CRC) is the 4th most commonly detected cancer in the USA. Despite promising advances, the 5-year survival rate for the metastatic disease remains dismal (<15%) due to the presence of chemo-resistant and ... -
Diffuse optical tomography to monitor the photocoagulation front during interstitial photothermal therapy: Numerical simulations and measurements in tissue-simulating phantoms
(De Gruyter, 2014-08-06)Near-infrared interstitial photothermal therapy (PTT) is currently undergoing clinical trials as an alternative to watchful waiting or radical treatments in patients with low/intermediate-risk focal prostate cancer. ... -
Finding key characteristics of promising compounds for anticancer drug discovery
(2017-12)Multidrug resistance is the simultaneous resistance to two or more chemically unrelated therapeutics, including some therapeutics the cell has never been exposed to. It is one of the biggest obstacles to effective cancer ... -
Impact of ferroptosis induction on iron metabolism in cancer cells harboring TP53 mutations
(2020-12)The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer, but mutations in TP53 do not just result in loss of tumor suppressor function, they can also promote cancer progression by altering cellular ... -
In vivo trans-rectal ultrasound-coupled near-infrared optical tomography of intact normal canine prostate
(World Scientific Publishing, 2009-07-01)This is the first tomography-presentation of the optical properties of a normal canine prostate, in vivo, in its native intact environment in the pelvic canal. The imaging was performed by trans-rectal near-infrared (NIR) ... -
In vivo trans-rectal ultrasound-coupled optical tomography of a transmissible venereal tumor model in the canine pelvic canal
(SPIE, the international society for optics and photonics, 2009-05-01)In vivo trans-rectal near-infrared (NIR) optical tomography was performed concurrently with, albeit reconstructed without spatial a prior of, trans-rectal ultrasound (US) on transmissible venereal tumor (TVT) developed as ... -
Influence of HDAC inhibition on the maintanance of iron homeostasis and the acquisition of oncogenic phenotype in cancer cells
(2021-12)Epithelial-to-mesenchymal transition (EMT), an essential mechanism for development and wound healing, but in cancer it also mediates the progression and spread of aggressive tumors while increasing therapeutic resistance. ... -
Nano-Polymeric Biomaterials Used in Cancer Drug Delivery Undergraduate
(2021-05-04)Cancer drug delivery therapy has become an increasingly researched field. Between the understanding of how nanomedicine can be used in cancer therapies, and the needs of a polymer to deliver drugs to targeted organs and ... -
NOVEL TARGETED ANNEXIN V - DRUG CONJUGATE FOR CANCER CHEMOTHERAPEUTIC TREATMENT
(2019)One of the most ubiquitous biomarkers of cancer is phosphatidylserine. It is expressed exclusively on the inner membrane leaflet of healthy vasculature, but tumor endothelium externalizes phosphatidylserine, taking advantage ... -
Novel targeted annexin V–nanoparticle conjugate for cancer photophermal therapy
(2020-12-18)Triple negative breast cancer represents a strong clinical challenge due to its high invasiveness and the lack of therapeutic targets. To overcome this problem, recent combination therapeutic strategies have been implemented. ... -
Portable near-infrared diffusive light imager for breast cancer detection
(SPIE, the international society for optics and photonics, 2004-02-03)We present a frequency-domain near-infrared optical tomography system designed for breast cancer detection, in conjunction, with conventional ultrasound. It features fast optical switching, threewavelength excitations, and ... -
Relationship of cortisol to psychological adjustment in parents of children diagnosed with cancer
(2012-07)Scope and Method of Study: The current study examined the relation of physiological stress as measured by salivary cortisol in a sample of parents of children who had been diagnosed and receiving treatment for pediatric ... -
Relationship of Parental Overprotection, Child Vulnerabililty, and Parenting Stress to Emotional, Behavioral, and Social Adjustment in Children Diagnosed with Cancer
(Oklahoma State University, 2005-12-01)This study examined the relationship of parental overprotection, perceived child vulnerability, and parenting stress to parent-reported emotional, behavioral, and social functioning in children with cancer. Parenting stress ... -
Rigor and reproducibility of cancer medicine evidence
(2021-05)The burden of cancer in the United States and abroad is comprised of significant morbidity, mortality, and psychological or financial harms. There remains a concern that the influence of published research is not maximized ... -
Social relationships and health-related behavior in adolescents with cancer
(2007-07)Scope and Method of Study: The purpose of the current study was to provide an examination of how dimensions of close peer and dating relationships (i.e., social support, negative interactions, dating anxiety, fear of ... -
Structure guided design of improved anticancer compounds
(Oklahoma State University, 2019-04-26) -
Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate. Part I: Simulation
(Optica Publishing Group, 2008-10-15)We investigate the feasibility of trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator that is to be integrated with a trans-rectal ultrasound (TRUS) probe. Integration with ...