Browsing by Subject "antibacterial agent"
Now showing items 1-7 of 7
-
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity
(American Society for Microbiology, 2009-07)Bacillus anthracis possesses an innate resistance to the antibiotic trimethoprim due to poor binding to dihydrofolate reductase (DHFR); currently, there are no commercial antibacterials that target this enzyme in B. ... -
Effects of localized Pasteurella haemolytica infection on erythromycin-binding properties of bovine alpha-1-acid glycoprotein, albumin, serum, and tissue chamber fluids
(American Society for Microbiology, 1994-10)The in vitro erythromycin-binding properties of bovine alpha-1-acid glycoprotein (AAG) and albumin were studied by using equilibrium dialysis. In addition, the proportions of free erythromycin in bovine serum and tissue ... -
Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis
(American Society for Microbiology, 2010-12)Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment ... -
In vitro efficacy of antibiotics commonly used to treat human plague against intracellular Yersinia pestis
(American Society for Microbiology, 2011-08)Yersinia pestis initiates infection as a facultative intracellular parasite in host macrophages; however, little is known about the efficacy of antibiotics commonly used to treat human plague against intracellular Y. pestis. ... -
In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis
(American Society for Microbiology, 2007-12)Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm ... -
Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities
(American Society for Microbiology, 2013-04)Cationic antimicrobial peptides are essential components of the innate immune system. As a major family of mammalian antimicrobial peptides, defensins are expressed mainly by mucosal epithelial cells and promyelocytes. ... -
Tick acquisition of Ehrlichia canis from dogs treated with doxycycline hyclate
(American Society for Microbiology, 2007-09)Doxycycline generally alleviates clinical monocytic ehrlichiosis, but its efficacy in the control of monocytotropic ehrlichial pathogens requires further investigation. In this study, Ehrlichia canis was detected in dogs ...