Browsing by Subject "Metabolomics"
Now showing items 1-9 of 9
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Application of untargeted metabolomics techniques based on LC-MS/MS to parasitic diseases and drug development
(2023-08-04)Metabolites are small chemical molecules less than 1500 Da such as carbohydrates, lipids, and amino acids that provide different functions in organisms. These metabolites are the products of host metabolism or received ... -
Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies
(2021-10-26)The success of natural product-based drug discovery is predicated on having chemical collections that offer broad coverage of metabolite diversity. We propose a simple set of tools combining genetic barcoding and metabolomics ... -
DEVELOPMENT AND APPLICATION OF SINGLE CELL MASS SPECTROMETRY TECHNIQUES FOR NON-ADHERENT CELL ANALYSIS
(2020-07)Mass spectrometry (MS) analysis of biological samples is traditionally carried out using extractions from large populations of cells, concealing the information from individual cells. In contrast, the drawbacks of traditional ... -
Mass spectrometry-based metabolomics analysis of Chagas disease models
(2024-05-10)Chagas disease (CD) is a neglected tropical disease which is caused by the parasite Trypanosoma cruzi. Approximately 6 to 7 million people in the world are infected with T. cruzi. The symptoms at the acute phase are mild ... -
METABOLOMIC ANALYSIS OF LIVE SINGLE CELLS AND SPHEROID SECRETIONS USING MASS SPECTROMETRY: TOWARDS UNDERSTANDING OF CELLULAR METABOLISM
(2019-05-10)This dissertation describes the single cell metabolomics analysis and microscale extracellular metabolites analysis using the Single-probe mass spectrometry (MS) techniques. Chapter one summarizes the current ... -
Metabolomic and phylogenetic analyses to better inform the construction of natural products discovery libraries
(2021-08-05)Natural product discovery programs rely on diverse libraries of organisms to provide access to a diverse pool of compounds. The quality and chemical diversity of these libraries are therefore of utmost importance to the ... -
SINGLE CELL METABOLOMICS USING MASS SPECTROMETRY: DEVICES, METHODS AND APPLICATIONS
(2019-05-10)Cells are basic functional components of eukaryotic organisms containing rich biological and physiological information. To investigate the nature of cells, a variety of fundamental and mechanistic studies of the cell ... -
Single-probe Mass Spectrometry Imaging: Applications and Advanced Data Analysis
(2019-12)Mass spectrometry imaging (MSI) is becoming a powerful tool in the bioanalytical studies owing to its unique capability to sensitively map the spatial distribution of broad ranges of molecules on biological samples. Due ... -
Studies in Anthropological Metabolomic and Microbial Approaches
(2023-05-12)Human biology is shaped by layers of interacting biomolecules, from genes to proteins and small molecules called metabolites. These molecules are crucial participants in biochemical reactions, representing biological ...