Browsing by Subject "Heme"

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    • Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis 

      Donegan, Rebecca K.; Fu, Yibo; Copeland, Jacqueline; Idga, Stanzin; Brown, Gabriel; Hale, Owen F.; Mitra, Avishek; Yang, Hui; Dailey, Harry A.; Niederweis, Michael; Jain, Paras; Reddi, Amit R. (American Society for Microbiology, 2022-10-26)
      Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...

    • PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis 

      Mitra, Avishek; Speer, Alexander; Lin, Kan; Ehrt, Sabine; Niederweis, Michael (American Society for Microbiology, 2017-03-08)
      Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ...