Browsing by Subject "Biological and endogenous factors"

Now showing items 1-5 of 5

    • Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis 

      Donegan, Rebecca K.; Fu, Yibo; Copeland, Jacqueline; Idga, Stanzin; Brown, Gabriel; Hale, Owen F.; Mitra, Avishek; Yang, Hui; Dailey, Harry A.; Niederweis, Michael; Jain, Paras; Reddi, Amit R. (American Society for Microbiology, 2022-10-26)
      Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...

    • Mycobacteria, metals, and the macrophage 

      Neyrolles, Olivier; Wolschendorf, Frank; Mitra, Avishek; Niederweis, Michael (Wiley, 2015-03)
      Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ...

    • PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis 

      Mitra, Avishek; Speer, Alexander; Lin, Kan; Ehrt, Sabine; Niederweis, Michael (American Society for Microbiology, 2017-03-08)
      Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ...

    • Role for zinc transporter gene SLC39A12 in the nervous system and beyond 

      Davis, Danielle N.; Strong, Morgan D.; Chambers, Emily; Hart, Matthew D.; Bettaieb, Ahmed; Clarke, Stephen L.; Smith, Brenda J.; Stoecker, Barbara J.; Lucas, Edralin A.; Lin, Dingbo; Chowanadisai, Winyoo (Elsevier, 2021-10-05)
      The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the vertebrate nervous system. As a zinc transporter, ZIP12 functions to transport zinc across ...

    • Role of the Mycobacterium tuberculosis ESX-4 secretion system in heme iron utilization and pore formation by PPE proteins 

      Sankey, November; Merrick, Haley; Singh, Padam; Rogers, Janet; Reddi, Amit; Hartson, Steven D.; Mitra, Avishek (American Society for Microbiology, 2023-02-07)
      Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb ...