Browsing by Author "Harrison, Roger"
Now showing items 1-20 of 25
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Advancing Annexin-Directed Enzyme Prodrug Therapy for the Treatment of Solid Tumors
Guillen, Katrin (2015-05)By targeting enzymes to the surface of tumor cells, tumor vasculature, and metastatic lesions, annexin-directed enzyme prodrug therapy aims to create high-dose chemotherapy only in the direct vicinity of the tumor site and ... -
Biomaterial and Computational Based Strategies for the in vitro Development of Bone Tissue and Tumor Engineered Constructs
Williams, Cortes III (2017-12)Every year in the United States, more than 500,000 bone graft surgeries are required. In most cases, bone will regenerate after fracture with minimal complications; however, when there is a critical-sized defect or fracture ... -
Design of a novel bioreactor for rotator cuff tendon tissue engineering
Liu, Jin (2018)Rotator cuff tears are a common cause of pain and disability due to injury and degradation of rotator cuff tendons. More than 250,000 patients require surgery each year, a majority of whom are over the age of 40. The current ... -
Development and Preclinical Evaluation of Enzyme Prodrug Therapies Targeted to the Tumor Vasculature
Krais, John (2014)Breast cancer is a global health concern of high prevalence that lacks safe and effective therapies for advanced cases. A targeted enzyme prodrug therapy aims to address this issue using an enzyme localized to the tumor ... -
The Development of a Combined Approach for the Real-Time, Non-Destructive Monitoring of In Vitro Bone Tissue Engineered Constructs Utilizing Physio-Metabolic Markers
Simmons, Aaron (2016-08)Annually, over $2.5 billion is spent on more than 500,000 bone grafts in the US alone, with more than 2 million being implanted worldwide. The limited supply of autografts and complications associated with traditional ... -
DEVELOPMENT OF BENCHTOP CAPILLARY-BASED ANALYTICAL INSTRUMENTS FOR CHROMATOGRAPHIC SEPARATION AND DETECTION
Lynch, Kyle (2018-05-01)Point-of-Care (POC) analysis in recent years has driven the need for the miniaturization of chemistry instruments in the analytical field. One such instrument class involves chromatographic systems for the separation and ... -
Development of Contrast Agents for Optoacoustic Imaging
MacCuaig, William (2023-12-15)Optoacoustic imaging is an emerging modality with inherent advantages relevant for clinical use. Following excitation of optoacoustic contrast agents with ultrashort (~10 ns) pulses of near-infrared light, thermoelastic ... -
DEVELOPMENT OF NANOSTRUCTURED ENZYMATIC BIOFUEL CELLS
Chen, Jie (2014-12-12)Nanostructured enzymatic biofuel cells with high power density output and prolonged lifetime were developed by the incorporation of carbon nanotubes into redox polymer-enzyme films. The performance of the enzymatic biofuel ... -
EFFECTS OF FLOW RATE ON MESENCHYMAL STEM CELL OXYGEN CONSUMPTION RATES IN 3D BONE TISSUE ENGINEERED CONSTRUCTS CULTURED IN PERFUSION BIOREACTOR SYSTEMS
Felder, Michael (2019-05)Bone grafts comprise a multibillion dollar industry, with over a million grafts occurring each year around the world. These grafts are commonly autologous or allogenic. Autologous grafts are taken from the patient, and are ... -
Effects of Short Exposure to High Shear on Neutrophil State and Function
Lewis, Christopher (2018)Cardiovascular disease is an ever expanding global issue. Many pathological conditions have been recently linked to elevated local shear rates (>3,000 s-1). Such vulnerable regions have also been found in mechanical support ... -
Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs
Nguyen, Hoai (2015)Cardiovascular diseases, including acute myocardial infarction, stroke, peripheral arterial diseases, and pulmonary embolism, are the most common and growing cause of morbidity and mortality in the United States. Early ... -
Exploring immunosuppresion with 3D in vitro T-cell attachment and exosome co-culture in dynamic bioreactor flow
Karami, Daniel (2020-12-18)Cancer is a prevalent disease that impacts many lives all over the world, projected to pass more than 27 million deaths in 2030. Among many cancer therapies and treatment solutions are immunotherapies, which can include ... -
A global optimization framework for stochastic integrated refinery planning with nonlinear unit models under demand and price uncertainties
Siamizade, Mahmud Reza (2020-09-11)The refining industry is facing increased volatility in the global market such as lower economic margins. In this situation, refinery production planning becomes a substantial tool to utilize all potentials to extend the ... -
Lipid-based nanoparticles for tissue regeneration and cancer photothermal therapy
Zhai, Mengmeng (2020-05-07)Exosome, a cell budded nanovesicle in diameter around 30 nm to 200 nm, has been found useful for the gene and drug delivery in bone tissue regeneration and cancer therapy. Exosome derived from donor cells has some specific ... -
M13 BACTERIOPHAGE-BASED POLYMERS, A PROMISING NEXT GENERATION OF BIOHYDROGEL
Cho, James (2018-12-14)Hydrogel has been considered a promising material for many biomedical applicational researches due to its unique properties. One such promising hydrogel is a peptide-based hydrogel due to its excellent biocompatibility and ... -
Mechanostimulation of a Tendon Tissue Engineered Human Umbilical Vein
Coffey, Chelsea (2017-12)Tissue engineering has become a very popular method when combined with bioreactors for treating disorders of the musculoskeletal system. A scaffold that is biocompatible and bio-absorbable is seeded with the cells then ... -
Novel annexin A5 - nanoparticles conjugates for targeted cancer therapy
Nogueira Furtado e Faria, Gabriela (2022-12-09)Cancer is considered the single most critical barrier to improving life expectancy in every country. More specifically, the high prevalence of breast cancer is a global health concern, but there are no safe or effective ... -
A NOVEL SCAFFOLD FOR GENERATION OF 3D TUMOR CONSTRUCTS
Jalanti, Alison (2017-06-16)Cancer is the second most common cause of death in the United States, leading to over $440 million in annual funding for research and yet anticancer drug development is an unmet need. In order to find a more effective way ... -
NOVEL TARGETED ANNEXIN V - DRUG CONJUGATE FOR CANCER CHEMOTHERAPEUTIC TREATMENT
Southard, Benjamin (2019)One of the most ubiquitous biomarkers of cancer is phosphatidylserine. It is expressed exclusively on the inner membrane leaflet of healthy vasculature, but tumor endothelium externalizes phosphatidylserine, taking advantage ... -
Phosphatidylserine Targeted Biotechnology Agents for Cancer
Virani, Needa (2017-08-16)Cancer is a highly mutating disease that quickly develops resistance to chemotherapies and has a high rate of relapse. If detected early, the survival rate is greater than 90% for most cancers; however if diagnosed during ...