Browsing by Author "Cichewicz, Robert H."
Now showing items 1-4 of 4
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Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies
Anderson, Victoria M.; Wendt, Karen L.; Najar, Fares Z.; McCall, Laura-Isobel; Cichewicz, Robert H. (2021-10-26)The success of natural product-based drug discovery is predicated on having chemical collections that offer broad coverage of metabolite diversity. We propose a simple set of tools combining genetic barcoding and metabolomics ... -
Design and Generation of Peptidomimetic ClpP Activator and N-Phenyl-1-Naphthylamine Libraries as Tools for Understanding Physicochemical Properties that Influence Gram-negative Accumulation
Gibaut, Quentin M. R. (2020-06)Gram-negative bacteria pose a major threat to human health as they demonstrate low sensitivity to most antibiotics. This lack of sensitivity to antimicrobials is largely due to the amphipathic membrane architecture and ... -
Genomic and Metabolomic Insights into the Natural Product Biosynthetic Diversity of a Feral-Hog-Associated Brevibacillus laterosporus Strain
Theodore, Christine M.; Stamps, Blake W.; King, Jarrod B.; Price, Lauren S. L.; Powell, Douglas R.; Stevenson, Bradley S.; Cichewicz, Robert H. (2014-03-03)Bacteria associated with mammals are a rich source of microbial biodiversity; however, little is known concerning the abilities of these microbes to generate secondary metabolites. This report focuses on a bacterium isolated ... -
Local Phenomena Shape Backyard Soil Metabolite Composition
Nguyen, Tra D.; Lesani, Mahbobeh; Forrest, Ines; Lan, Yunpeng; Dean, Danya A.; Gibaut, Quentin M. R.; Guo, Yanting; Hossain, Ekram; Olvera, Marcela; Panlilio, Hannah; Parab, Adwaita R.; Wu, Chaoyi; Bernatchez, Jean A.; Cichewicz, Robert H.; McCall, Laura-Isobel (2020-02-29)Soil covers most of Earth’s continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil ...