Browsing by Author "Cichewicz, Robert"
Now showing items 1-20 of 28
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Advancement of Natural Products: Optimization of Instrumentation and Examples of their Application to the Isolation of New Compounds
Mattes, Allison (2019)The world of natural products has a long rich history dating back thousands of years and was the origin of medicine as we know it. Advancements in the field of natural products can be seen not only in the isolation of new ... -
Bioactive Molecules Detection and Identification in Complex Biological Systems through Activity-Based Metabolomics and Proteomics
Ma, Hongyan (2020-07)The detection and identification of bioactive molecules (e.g. therapeutic small-molecule lead compounds, functional proteins) from complex mixtures is often a critical step in various biochemical and biomedical research ... -
THE BIOCHEMICAL CHARACTERIZATION OF TWO PHOSPHORELAY SIGNALING PROTEINS: YPD1 HOMOLOGS FROM SACCHAROMYCES CEREVISIAE AND CRYPTOCOCCUS NEOFORMANS
Kennedy, Emily (2016-08)Histidine-to-aspartate multi-step phosphorelay systems are used extensively by eukaryotes and bacteria to sense and respond to changes in their external environment and to control the regulation of crucial biological ... -
Characterization and bioinformatic analysis of Pseudomonas aeruginosa condensins
Clevenger, April (2019-12)DNA is organized within chromosomes not only to permit a large amount of DNA to occupy a very small space, but also to serve essential functional roles. Varied levels of organization enable proper DNA replication, repair, ... -
Characterizing the effect of habitat structure on microbial community assembly and secondary metabolism for natural product discovery
Junkins, Emily (2021-08)Microorganisms exist in dynamic networks that catalyze reactions and respond to stimuli. They organize into populations that make up the microbial communities we know to drive large-scale biogeochemical cycles that can ... -
A COMPUTATIONAL APPROACH FOR ACCESSING PHOSPHORYLATED RESPONSE REGULATOR CONFORMATIONS AND SIGNALING COMPLEXES INVOLVING THE FUNGAL PHOSPHORELAY PROTEIN YPD1
Foster, Clay (2016-08)Two-component signaling is the primary means by which bacteria, archaea and certain eukaryotes sense and respond to their environments. Signal transfer proceeds through sequential His-to-Asp phosphorylation of upstream ... -
DESIGN AND SYNTHESIS OF NEW CLPP ACTIVATORS: TOWARDS THE DEVELOPMENT OF A COMPUTATIONALLY GUIDED APPROACH
Avila, Quentin P. (2016-12)With the rise of antibiotic-resistant bacteria, there is an urgent need to develop antibacterials with new mechanisms of action. Because of its essential role in bacterial survival and the possibility to induce unselective ... -
Development of synthetic methodologies for N- to C-terminal cyclization of peptidomimetic small molecules and in silico and in vitro studies of the role of cyclization on antibacterial and antiviral activities
Avila, Quentin Paul (2022-05-13)Among the different mechanisms of resistance in Gram-negative bacteria, the permeability barrier of the outer membrane and efflux pumps represent a significant challenge to address as they synergize to reduce accumulation ... -
Distributions and Bioaccumulation of Microcystins
Glidewell, Dani (2022-05-13)Microcystins are hepatotoxins and tumor promotors, with various deleterious effects on plants as well. There are 270+ known congeners of the toxin microcystin, structural variants of the molecule. These hepatotoxins are ... -
DNA Barcoding Identification and Chemical Investigation of Fungi
Dai, Wentao (2019-05-10)Fungi represent a diverse resource in the discovery of new secondary metabolites which have been successfully developed as drugs such as antibiotics, immunosuppressant and stains. However, there are still problems which ... -
Ferrocene-Modified Linear Poly(ethylenimine) Bioelectrode Materials for Use in Glucose/O2 Biofuel Cells
Hickey, David (2014-04-21)Tetramethylferrocene-modified linear(polyethylenimine) (FcMe4-C3-LPEI) was cross-linked with ethylene glycol diglycidyl ether (EGDGE) in the presence of glucose oxidase (GOx) on carbon electrodes to form enzymatic redox ... -
Impact of environmental (pH) change in a model aquatic herbivore: from genes to populations
Culver, Billy Jr (2016-05)Organisms are subjected to a variety of environmental stressors in which they must respond in order to survive and reproduce. While some individuals are able to adjust to these stressors and live to produce offspring and ... -
INVESTIGATION OF BIOACTIVITIES AND INDUCTION OF NEW METABOLITES IN FUNGI
Bielak, Krzysztof (2016-12)In these studies, three different problems are looked at: the need for new compounds to treat infections caused by the Trichomonas vaginalis parasite, the development of methodology to induce production of new metabolites, ... -
Investigations of Secondary Metabolites from Fungi: Isolation, Structure Elucidation, and Computational Studies
Carter, Adam (2018-12-14)Natural products have served as therapeutic agents in the treatment of many human health ailments for thousands of years. In order to find new therapeutic agents for future human health problems, those in the field of ... -
Investigations of secondary metabolites from fungi: isolation, structure elucidation, and semi-synthetic studies
Peramuna, Peramunu (2022-12-16)Trichomoniasis, caused by Trichomonas vaginalis remains a worldwide threat, afflicting an astonishing 3.9% of the world’s population. This parasite is recognized as a cause of vaginitis and can result in serious health ... -
Isolation and structural analysis of secondary metabolites from the fungi Aspergillus terreus and Remersonia thermophila
Mangione, Melvynn (2022-05-13)Aspergillus terreus has shown to inhibit M. genitalium whereas Remersonia thermophila has shown to exhibit antitrichomonal activity. The compounds that were responsible for activity in their respective assays were rapidly ... -
THE LIGAND BINDING PROPERTIES OF THE OXYSTEROL-BINDING PROTEIN FAMILY SUBFAMILY-I
Nunez, Juan (2018-12-14)The oxysterol-binding protein/OSBP-related proteins (OSBP/ORPs) are a family of proteins conserved in all eukaryotes that have complex biological activities connected to lipid transport and lipid regulation. OSBP is ... -
Mass spectrometry-based metabolomics analysis of Chagas disease models
Liu, Zongyuan (2024-05-10)Chagas disease (CD) is a neglected tropical disease which is caused by the parasite Trypanosoma cruzi. Approximately 6 to 7 million people in the world are infected with T. cruzi. The symptoms at the acute phase are mild ... -
Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps
Ntreh, Abigail (2016-08)Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of ... -
Metabolomic and phylogenetic analyses to better inform the construction of natural products discovery libraries
Anderson, Victoria (2021-08-05)Natural product discovery programs rely on diverse libraries of organisms to provide access to a diverse pool of compounds. The quality and chemical diversity of these libraries are therefore of utmost importance to the ...