Browsing by Author "Bourne, Christina R."
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity
Bourne, Christina R.; Bunce, Richard A.; Bourne, Philip C.; Berlin, K. Darrell; Barrow, Esther W.; Barrow, William W. (American Society for Microbiology, 2009-07)Bacillus anthracis possesses an innate resistance to the antibiotic trimethoprim due to poor binding to dihydrofolate reductase (DHFR); currently, there are no commercial antibacterials that target this enzyme in B. ... -
A YoeB toxin cleaves both RNA and DNA
McGillick, Julia; Ames, Jessica R.; Murphy, Tamiko; Bourne, Christina R. (2021-02-11)Type II toxin-antitoxin systems contain a toxin protein, which mediates diverse interactions within the bacterial cell when it is not bound by its cognate antitoxin protein. These toxins provide a rich source of ...