Browsing by Author "Harrison, Roger"
Now showing items 21-25 of 25
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STUDIES UTILIZING DECELLULARIZED HUMAN AMNIOTIC MEMBRANE AND SW-620 CELLS AS A PRELUDE TO 3D IN VITRO CULTURES
Narum, Melissa (2017)The prevalence of cancer in modern society has increased from 14.1 million new diagnoses and 8.2 million deaths in 2012 to an estimated 21.7 million new diagnoses and 13 million cancer-related deaths projected in 2030. The ... -
TENDON TISSUE ENGINEERING: AN INVESTIGATION INTO ENHANCED BIOREACTOR CULTURE AND CONSTRUCT STIMULATION TECHNIQUES
Engebretson, Brandon (2014-06)Tendon tissue engineering is a field that arose as there became a need for alternatives for surgical grafts utilized in injured tendon treatments. This is due to either underperforming current technology of off the shelf ... -
Therapeutic Applications of Bioconjugates in Human Disease
McKernan, Patrick (2018-12-14)The unifying element tying together the therapeutics presented in this thesis is annexin A5. The protein, annexin 5 (ANXA5), is a membrane management protein that specifically binds to apoptotic cells. The natural ligand ... -
Translation and Development of Novel Annexin A5 - Protein Drug Conjugates for the Treatment of Triple-Negative Breast Cancer
Woodward, Alexis (2022-12-16)Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subset with limited targeted chemotherapies. TNBC is defined by the absence of the estrogen, progesterone, and HER2 hormonal receptors on the cell ... -
Utilizing Flow Perfusion Bioreactor Systems as Novel Platforms for Cancer Research
Bryant, Parker (2023-08-04)Cancer remains a leading cause of death worldwide, with no signs of slowing down. In 2023 alone, the projected number of deaths from cancer is 600,000, with projected incidences at almost 2 million. Mortality rates have ...