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Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts
(PLos One, 2015-08-06)
Pediatric glioblastomas (pGBM), although rare, are one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. Here, we describe the use of conventional and ...
The Sialic Acid Binding Protein, Hsa, in Streptococcus gordonii DL1 also Mediates Intergeneric Coaggregation with Veillonella Species
(PLos One, 2015-11-25)
Dental biofilm development involves initial colonization of the tooth’s surface by pioneer colonizers, followed by cell-cell coaggregation between the pioneer and later colonizers. Streptococcus gordonii is one of the ...
Justice and capabilities in the postcolony: Extending Sen to the Jamaican and South African contexts
(Philosophy & Social Criticism, 2015-01-01)
This article explores briefly the practical as well as theoretical issues that arise when Amartya Sen’s evaluation of justice through the capabilities afforded citizens in a society is applied to postcolonies like Jamaica ...
Hands on Testing (HOT) Pilot Project: Recommendations and Findings Final Report
(2015-04-20)
This report includes findings from a pilot project with three main objectives: (1) to develop standardized measures for the HOT test (child and adult interview), (2) to test of the reliability/validity of the newly developed ...
Functional Gene Composition, Diversity and Redundancy in Microbial Stream Biofilm Communities
(PLos One, 2015-04-07)
We surveyed the functional gene composition and diversity of microbial biofilm communities in 18 New Zealand streams affected by different types of catchment land use, using a comprehensive functional gene array, GeoChip ...
Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet
(PLos One, 2015-11-05)
Diabetes is a chronic inflammatory disease that carries a high risk of cardiovascular disease. However, the pathophysiological link between these disorders is not well known. We hypothesize that TLR4 signaling mediates ...
CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer
(PLos One, 2015-09-28)
Antiangiogenic therapy is important for the treatment of gynecological cancer. However, the therapeutic benefit derived from these treatments is transient, predominantly due to the selective activation of compensatory ...
Locke, Kant, and Synthetic A Priori Cognition
(2015)
This paper attempts to shed light on three related issues that bear directly on our understanding of Locke and Kant. The first is whether Kant believes Locke merely anticipates his distinction between analytic and synthetic ...
Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria
(PLos One, 2015-12-31)
Although diabetes has been identified as a major risk factor for atrial fibrillation, little is known about glucose metabolism in the healthy and diabetic atria. Glucose transport into the cell, the rate-limiting step of ...
Effects of a mechanical engineering design course on students’ motivational features
(International Journal of Mechanical Engineering Education, 2015-04-17)
Diverse learning opportunities and deep engagement are needed to support development of engineering competencies and expertise. Deep engagement evolves from productive and high-quality motivation that derives from both ...