Browsing OU - Faculty and Staff Publications by series "PLoS ONE 10(9): e0138437"
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FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia
(PLos One, 2015-09-22)Background Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived ...