Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus
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Date
2015-12-10Author
Wenhui Zheng
Jie Zhou
Yunlong He
Qiurong Xie
Ahai Chen
Huawei Zheng
Lei Shi
Xu Zhao
Chengkang Zhang
Qingping Huang
Kunhai Fang
Guodong Lu
Daniel J. Ebbole
Guangpu Li
Naweed I. Naqvi
Zonghua Wang
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Author Summary The rice blast fungus Magnaporthe oryzae utilizes key infection structures, called appressoria, elaborated at the tips of the conidial germ tubes to gain entry into the host tissue. Development of the appressorium is accompanied with autophagy in the conidium leading to programmed cell death. This work highlights the significance of the Vps35/retromer membrane-trafficking machinery in the regulation of autophagy during appressorium-mediated host penetration, and thus sheds light on a novel molecular mechanism underlying autophagy-based membrane trafficking events during pathogen-host interaction in rice blast disease. Our findings provide the first genetic evidence that the retromer controls the initiation of autophagy in filamentous fungi.
Citation
Zheng W, Zhou J, He Y, Xie Q, Chen A, Zheng H, et al. (2015) Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus. PLoS Genet 11(12): e1005704. doi:10.1371/journal.pgen.1005704