Effects of social defeat on iK-ba inflammatory signaling in male c57BL/6J
Date
2020-02-28Author
Johnson, Christopher
Davis, Randall
Buck, Daniel
McCracken, Kelly
Metadata
Show full item recordAbstract
An estimated 30 million people in the United States have been diagnosed with mood and anxiety disorders. Unfortunately, many of these patients do not adequately respond to current pharmacotherapies, so developing new drugs and strategies to treat such disorders is critically important. There are only a few drugs on the market that target neuroinflammation. Thus, it's critical that we identify anti-inflammatory agents that effectively reduce neuroinflammatory responses, hereby expanding or augmenting available options for treating neurological disorders. Previous work has shown that the derivative of naltrexone, B-funaltrexamine (B-FNA), inhibits inflammatory signaling in human astrocytes in reduced expression of proinflammatory chemokines. IKBa is one of the specific signaling proteins in the inflammation pathway.
Citation
Johnson, C., Davis, R., Buck, D., & McCracken, K. (2020, Feb. 28). Effects of social defeat on iK-ba inflammatory signaling in male c57BL/6J. Poster presented at Research Day at Oklahoma State University Center for Health Sciences, Tulsa, OK.
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- Research Day 2020 [86]