3-ethoxycarbonyl-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)pyridinium nitrate, dineopentyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate and dihexyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
Abstract
The single-crystal X-ray structures of three oxidation products of 4-(3-nitrophenyl)-1,4-dihydropyridine, namely, 3-ethoxycarbonyl-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)pyridinium nitrate, C18H19N2O6+.NO3-, dineopentyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C25H32N2O6, and dihexyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C27H36N2O6, suggest that their decreased calcium-blocking activity arises from incompatibility of the phenyl ring and ester conformation with the receptor site.
Citation
Rowan, K. R., & Holt, E. M. (1997). 3-ethoxycarbonyl-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)pyridinium nitrate, dineopentyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate and dihexyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate. Acta Crystallographica Section C - Crystal Structure Communications, 53(2), 257-261. https://doi.org/10.1107/S010827019601181X