Metabolic Risk Factors for Cardiovascular Disease in Oklahoma Adults with Abdominal Adiposity and Dyslipidemia: a Cross-sectional Study.

Abstract

Dietary intakes of fruits and vegetables have been shown to lower risks of cardiovascular complications in both epidemiological and clinical studies. In particular, the polyphenol subclass of flavonoids has been found to exert anti-atherosclerotic, anti-hypertensive, and anti-oxidative properties. Our study aims to further investigate the relationships among cardiovascular disease (CVD) risk factors, total servings of fruits and vegetables, as well as flavonoid intakes in Oklahoma adults with abdominal adiposity and dyslipidemia. Thirty participants (5 males, 25 females) were recruited at the General Clinical Reserch Center at the Oklahoma University Health Science Center and Department of Nutritional Sciences at the Oklahoma State University. Blood draws and anthropometrics were performed and participants completed a 3 day food records for dietary analysis.Serum total cholesterol, LDL-cholesterol and glucose levels were significantly different across tertiles of ox-LDL (p <0.05); total- and LDL-cholesterol were significantly higher in the highest vs. lowest tertiles. Waist circumference, serum glucose, HbA1c, quercetin intake, and total servings of fruits and vegetables were significantly different across tertiles of CRP (p <0.05); elevated levels in highest vs. lower tertiles. This cross-sectional study shows significant differences among measures of lipid oxidation, CRP, and flavonoids (kaempferol, myricetin, quercetin) with measures of lipids and glycemic control in Oklahoma adults with abdominal adiposity and dyslipidemia. Further investigation with a large population should be conducted to confirm these findings.