Browsing by Subject "n-terminal inhibitors"

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    • Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells 

      Eskew, Jeffery D.; Sadikot, Takrima; Morales, Pedro; Duren, Alicia; Dunwiddie, Irene; Swink, Megan; Zhang, Xiaoying; Hembruff, Stacey; Donnelly, Alison; Rajewski, Roger A.; Blagg, Brian S. J.; Manjarrez, Jacob R.; Matts, Robert L.; Holzbeierlein, Jeffrey M.; Vielhauer, George A. (BioMed Central, 2011-10-31)
      Background: The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, ...