Yan Ping ChenJeffery S. PettisMiguel CoronaWei Ping ChenCong Jun LiMarla SpivakP. Kirk VisscherGloria DeGrandi-HoffmanHumberto BoncristianiYan ZhaoDennis vanEngelsdorpKeith DelaplaneLeellen SolterFrancis DrummondMatthew KramerW. Ian LipkinGustavo PalaciosMichele C. HamiltonBarton SmithShao Kang HuangHuo Qing ZhengJi Lian LiXuan ZhangAi Fen ZhouLi You WuJi Zhong ZhouMyeong-L. LeeErica W. TeixeiraZhi Guo LiJay D. Evans2016-01-082016-03-302016-01-082016-03-302014-07-31Chen YP, Pettis JS, Corona M, Chen WP, Li CJ, Spivak M, et al. (2014) Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health. PLoS Pathog 10(7): e1004261. doi:10.1371/journal.ppat.1004261http://hdl.handle.net/11244/23536Author Summary The mysterious outbreak of honey bee Colony Collapse Disorder (CCD) in the US in 2006–2007 has attracted massive media attention and created great concerns over the effects of various risk factors on bee health. Understanding the factors that are linked to the honey bee colony declines may provide insights for managing similar incidents in the future. We conducted this study to elucidate traits of a key honey bee virus, Israeli acute paralysis virus. We then developed an innovative strategy to control virus levels. The knowledge and insights gained from this study will have positive implications for bee disease management, helping to mitigate worldwide colony losses.en-USAttribution 3.0 United StatesHoney bees,Bees,Gene expression,Small interfering RNAs,Sequence motif analysis,Invertebrate genomics,Mites,Reverse transcriptase-polymerase chain reactionResearch Article10.1371/journal.ppat.1004261false