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Investigation of the microbial and molecular correlates of Morgellons disease
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Morgellons disease is a complex dermopathy that is controversial in the medical community. Unfortunately, there is not enough evidence to the etiology or transmission of this disease. Due to the lack of information, the ...
Clinical trial discontinuation and non-publication for the pharmacologic treatment of Post-Traumatic Stress Disorder among military veterans
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Background: Failures by researchers and clinicians to understand, confront, and overcome barriers in veteran-health research may result in the waste of finite resources. Research waste includes clinical trial discontinuation ...
Morphine potentiates glucocorticoid receptor translocation in neuronal cells
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Background: The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in regulating signaling by glucocorticoid receptor which is expressed in almost all cells. Adrenocorticotropin hormone (ACTH) and β-endorphin ...
Correlation between gluteus medius strength and lower back pain in middle-aged adults: a critically appraised topic
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Background: Low back pain is one of the most common complaints of middle-aged individuals. Low back pain tends to be the result of a more sedentary lifestyle and even for those who are active, normal biomechanics can often ...
Investigation of acetate sensitivity within shf1 Chlamydomonas mutants
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Cilia and flagella are essential for human health. Defects in the assembly and function of these organelles are associated with a collection of disorders called ciliopathies. Studies have suggested that regulation of ciliary ...
Cultural pathway to osteopathic medical school: The Native American pre-admissions workshop
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Background: Native Americans (NAs) experience significant health disparities compared to the general US population. Medical education has a key role to play in addressing these inequities; however, it is currently falling ...
Detection of RNA methylation patterns of forensically relevant transcripts in dried bloodstains
(Oklahoma State University Center for Health Sciences, 2022-02-18)
RNA degradation kinetics can be used to estimate the age of a biological sample found at a crime scene. RNA sequencing of transcripts from various tissue types shows that degradation occurs faster at the 5’ end than the ...
Analyzing the phenotypic characteristics of environmental C. difficile isolates
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Clostridioides difficile (C. difficile) is an anaerobic, spore-forming bacterium. Antibiotic use, hospitalization, advanced age, a compromised immune system, and previous infection puts individuals at an increased risk for ...
Effects of gram-negative bacterial outer membrane permeabilization on Serratia marcescens' gene expression
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Our laboratory has focused on understanding the effects of outer membrane permeabilizer compound 48/80 on the intrinsic resistance of gram-negative bacteria to hydrophobic antibacterial agents such as the biocide triclosan. ...
Synthetic cannabinoid, WIN 55212-2, leads to changes of proBDNF/BDNF ratio levels in the periaqueductal gray and blood concentrations in the adolescent rat
(Oklahoma State University Center for Health Sciences, 2022-02-18)
Background: The hemp plant Cannabis sativa—marijuana and hashish are among the most commonly used illicit substances in adolescents and young adults. The synthetic CB1 agonist WIN 55212-2 (WIN) administration to rats and ...