Browsing OU - Dissertations by Subject "Saccharomyces cerevisiae"
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Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae
(2009)The multi-step His-Asp phosphorelay system in Saccharomyces cerevisiae allows cells to adapt to osmotic, oxidative and other environmental stresses. The pathway consists of a hybrid histidine kinase SLN1, a histidine-containing ... -
KINETIC STUDIES OF SACCHAROPINE REDUCTASE
(2009)Saccharopine reductase (SR) (EC 1.5.1.10) is the penultimate enzyme in the L-αaminoadipate pathway encoded by the LYS9 gene in Saccharomyces cerevisiae. Saccharopine reductase (SR) catalyzes the condensation of ... -
Mechanisms of enzymes of the a-aminoadipate pathway: Homocitrate synthase from Thermus thermophilus and saccharopine dehydrogenase from Saccharomyces cerevisiae
(2011)The &alpha-aminoadipate (AAA) pathway for lysine biosynthesis is nearly unique to higher fungi, including human and plant pathogens and euglenoids; an exception is the thermophilic bacterium Thermus thermophilus. . ... -
MECHANISTIC AND STRUCTURAL STUDIES OF SACCHAROPINE DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE
(2010)Lysine is an essential amino acid in mammals including humans. The α-aminoadipate (AAA) pathway for lysine biosynthesis is unique to fungal organisms and enzymes of this pathway are of interest as potential targets ... -
PROBING THE MECHANISM OF SACCHAROPINE DEHYDROGENASE FROM Saccharomyces cerevisiae USING SITE-DIRECTED MUTAGENESIS
(2010)Saccharopine dehydrogenase (SDH) catalyses the NAD-dependent oxidative deamination of saccharopine to give L-lysine and alpha-ketoglutarate. There are a number of conserved hydrophilic, ionizable residues in the active ...